Australian Natural Bodz - - Contents -

Pre-work­out sup­ple­men­ta­tion with tea or ca­cao may lead to a higher con­cen­tra­tion of the an­abolic hor­mone testos­terone in the body, and as a re­sult a lit­tle bit more mus­cle growth. We base this bold state­ment on a test-tube study that re­searchers at Kingston Univer­sity in Lon­don will soon pub­lish in jour­nal Steroids. Painkillers such as di­clofenac and ibupro­fen in­hibit the en­zyme UGT2B17, which at­taches sugar molecules to testos­terone, thereby neu­tral­is­ing its ef­fect. Th­ese two painkillers can help boost the testos­terone level for a short time, though what di­clofenac and ibupro­fen can do, can prob­a­bly also be done by sub­stances found in food, sus­pect the Brits. Polyphe­nols such as epi­cat­e­chin, a sub­stance found in ca­cao and green and white tea, and EGCG [struc­tural for­mula be­low right], a com­pound found in green and white tea, in­hibit lots of en­zymes, so why not the en­zyme UGT2B17? The con­cen­tra­tion of th­ese phe­nols can rise to high lev­els in nor­mal hu­man bod­ies. If you drink seven cups of green tea a day you can have as much as 21.2 nanomoles per litre of the tea flavonoid EGCG in your blood. [J Am Coll Nutr. 2005 Oct; 24(5): 342-6.] That is of the same or­der as the con­cen­tra­tion of testos­terone in the body of an adult man. Ac­cord­ing to a 2002 study done at the State Univer­sity of New Jersey, the con­cen­tra­tion of phe­nols such as epi­gal­lo­cat­e­chin-3-gal­late (EGCG), epi­gal­lo­cat­e­chin (EGC) and epi­cat­e­chin (EC) reaches max­i­mum lev­els 1-2 hours af­ter con­sum­ing a green-tea ex­tract. [Can­cer Epi­demiol Biomark­ers Prev. 2002 Oct; 11(10 Pt 1): 1025-32.] The lev­els are so high that they must have an ef­fect on en­zymes. The Brits de­cided to test it out. They bought dragon beard white tea (WT), Yun­nan white tea leaf (WTL), sen­cha Ja­panese green tea bags (GT) and white tea pow­der (WTP). The last men­tioned prod­uct was from Bur­gundy Botan­i­cal Ex­tracts, and was an ex­tract in­tended for cos­metic use. The re­searchers bought the other prod­ucts in an or­di­nary shop. They put 1.6 g tea in 80 ml boil­ing wa­ter, fil­tered out the leaves and used the cooled down tea for their tri­als. In test tubes both the tea that the re­searchers had brewed and the (WTP) ex­tract in­hib­ited the gly­co­sy­la­tion of testos­terone by UGT2B17. The white tea ex­tract in par­tic­u­lar worked well. When the re­searchers ex­am­ined some tea phe­nols sep­a­rately, they dis­cov­ered that EGCG was the strong­est UGT2B17 in­hibitor. EGCG per­formed as well as the anti-in­flam­ma­tory di­clofenac in a study we de­scribed pre­vi­ously. “A wider as­sess­ment of food­stuffs and their con­stituents for in­hibitory ac­tiv­ity against UGT en­zymes is war­ranted”, the Brits con­clude. A ‘wider as­sess­ment’ could be of con­sid­er­able in­ter­est to nat­u­ral ath­letes, as it would help give an idea of what an op­ti­mal pre-work­out diet should con­sist of. In the mean time adding green tea may help boost testos­terone lev­els dur­ing and af­ter train­ing re­sult­ing in greater pro­tein syn­the­sis, a big plus for nat­u­ral ath­letes. Source: Steroids. 2012 May;77(6):691-5.

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