Australian Natural Bodz - - Contents -

The leucine me­tab­o­lite HMB, ac­cord­ing to its dis­cov­er­ers, has a mild an­ti­catabolic and an­abolic ef­fect be­cause HMB stim­u­lates the syn­the­sis of choles­terol – a com­po­nent of cell mem­branes – in the mus­cle cells. Ac­cord­ing to an an­i­mal study done at the Fed­eral Univer­sity of Sao Paulo, the way in which HMB works is more com­plex. The Brazil­ians dis­cov­ered that HMB in­hibits cor­ti­sol and ac­ti­vates the clas­sic an­abolic sig­nal molecule mTOR. Sur­pris­ingly lit­tle re­search has been done on the mech­a­nism through which HMB works, and the Brazil­ians de­cided to try and fill this knowl­edge gap by do­ing an an­i­mal study. They gave male rats a daily oral dose of 340 mg HMB per kg body­weight ev­ery day for a month. This cor­re­sponds to a hu­man dose of 3-6 g per day. Dur­ing this pe­riod the rats did in­deed de­velop more mus­cles than those in the con­trol group, which had not been given HMB. The re­searchers found no ef­fects on fat mass, al­though they don’t ex­clude the pos­si­bil­ity of the HMB hav­ing re­duced fat de­posits some­where in the body where they hadn’t looked. The con­cen­tra­tion of the stress hor­mone cor­ti­sol de­creased by a sig­nif­i­cant amount in the an­i­mals’ blood. The testos­terone con­cen­tra­tion rose, but not sig­nif­i­cantly. The fast­ing in­sulin level rose by 245 per­cent. HMB boosted the pro­duc­tion of the an­abolic sig­nal molecule mTOR by 430 per­cent in the mus­cle cells of the lab an­i­mals. The num­ber of p70S6K molecules did not in­crease, but the molecules be­came

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