VI­TA­MIN D

DE­FI­CIENCY IN­CREASES RISK OF BONE FRAC­TURES

Australian Natural Bodz - - Health Sex & Longetivity -

Vi­ta­min de­fi­ciency is a wide­spread med­i­cal con­di­tion that plays a ma­jor role in hu­man bone health. Frac­ture sus­cep­ti­bil­ity in the con­text of low vi­ta­min

has been pri­mar­ily as­so­ci­ated with de­fec­tive min­er­al­iza­tion of col­lage­nous ma­trix (os­teoid). How­ever, bone’s frac­ture re­sis­tance is due to tough­en­ing mech­a­nisms at var­i­ous hi­er­ar­chi­cal lev­els rang­ing from the nano - to the mi­crostruc­ture. The in­crease in frac­ture risk with vi­ta­min D de­fi­ciency may be trig­gered by nu­mer­ous patho­log­i­cal changes and may not solely de­rive from the ab­sence of min­er­al­ized bone. The team col­lected sam­ples of iliac crest bone cores from 30 par­tic­i­pants, half of whom were de­fi­cient in vi­ta­min D and showed early signs of os­teo­ma­la­cia. For this study, a nor­mal vi­ta­min D level was de­fined as a serum con­cen­tra­tion of 20 mi­cro­grams per liter or higher. For the vi­ta­min D de­fi­ciency group the mean serum con­cen­tra­tion was 10 mi­cro­grams per liter. The re­searchers an­a­lyzed the bone sam­ples us­ing Fourier Trans­form In­frared (FTIR) spec­troscopy and X­ray com­puted mi­cro­to­mog­ra­phy, and found that while vi­ta­min D­de­fi­cient subjects had less over­all min­er­al­iza­tion due to a re­duc­tion of min­er­al­ized bone, un­der­neath the new non­min­er­al­ized sur­faces, the ex­ist­ing bone was ac­tu­ally more heav­ily min­er­al­ized, and dis­played the struc­tural char­ac­ter­is­tics – ma­ture col­la­gen mol­e­cules and min­eral crys­tals of older and more brit­tle bone. The study ex­pands the cur­rent clin­i­cal un­der­stand­ing of the patho­phys­i­ol­ogy of vi­ta­min D de­fi­ciency and helps ex­plain why well­bal­anced vi­ta­min D lev­els are es­sen­tial to main­tain bone’s struc­tural in­tegrity. Ref­er­ence: Bjorn Busse, Hr­ishikesh A. Bale, El­iz­a­beth A. Zim­mer­mann, Brian Pan­gani­ban, Holly D. Barth, Robert O. Ritchie, et al. “Vi­ta­min D De­fi­ciency In­duces Early Signs of Ag­ing in Hu­man Bone, In­creas­ing the Risk of Frac­ture.” Sci Transl Med, 10 July 2013, 5:193ra88.

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