AP­PLE COM­POUNDS COM­BAT IN­FLAM­MA­TION

Australian Natural Bodz - - Nutrition Knowledge Centre -

Ap­ple peel is an abun­dant source of triter­penoids – plant-based com­pounds for which anti-cancer ef­fects are sug­gested. Elke Rich­ling, from |Univer­sity of Kais­er­slautern (Ger­many), and col­leagues stud­ied the ef­fects of ur­sanic, oleanic and lu­panic pen­ta­cyclic triter­penoids found in ap­ple peel for their anti­in­flam­ma­tory ef­fects, us­ing colon cancer cells that were ex­posed to the triter­penoids and then stim­u­lated with pro­in­flam­ma­tory cy­tokines. Find­ing that the ap­ple peel com­pounds in­hib­ited the ex­pres­sion of IP­10, a gene that is linked to in­flam­ma­tory dis­or­ders in­clud­ing ir­ri­ta­ble bowel dis­ease, the study au­thors sub­mit that: “The present study con­firms that triter­penoids present in ap­ple peel … may be im­pli­cated in the anti­in­flam­ma­tory prop­er­ties of ap­ple con­stituents, sug­gest­ing that these sub­stances might be help­ful in the treat­ment of [ir­ri­ta­ble bowel dis­ease] as nutrient sup­ple­ments.” Even more ev­i­dence to back up the fa­mous quote “An ap­ple a day keeps the doc­tor away”. Ref­er­ence: Dolores Mueller, Sven Triebel, Olga Ru­dakovski, Elke Rich­ling. “In­flu­ence of triter­penoids present in ap­ple peel on in­flam­ma­tory gene ex­pres­sion as­so­ci­ated with in­flam­ma­tory bowel dis­ease (IBD).” Food Chem­istry, Vol­ume 139, Is­sues 1–4, 15 Au­gust 2013, Pages 339-346.

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