HIGH GLU­COSE EQUALS LOWER TESTOS­TERONE!

Australian Natural Bodz - - Nutrition Knowledge Centre -

If you have too much glu­cose in your blood, your body pro­duces less testos­terone. The mech­a­nism in­volved has been shown in an in-vitro study pub­lished by Ital­ian en­docri­nol­o­gists at the Univer­sity of Florence in the In­ter­na­tional Jour­nal of En­docrinol­ogy. If you want to boost your testos­terone level in a nat­u­ral way, make sure you don’t de­velop Type-2 di­a­betes and avoid ex­tremely high glu­cose peaks. The Ital­ians did the study be­cause they wanted to bet­ter un­der­stand why di­a­betes sufferers of­ten pro­duce lit­tle testos­terone, as a re­sult of which they may de­velop sex­ual prob­lems or in­fer­til­ity. They ex­per­i­mented with hu­man cells that pro­duce the go­nadotropin-re­leas­ing hor­mone [GnRH]. GnRH plays a key role in the body’s re­lease of testos­terone. In the brain the hy­po­thal­a­mus re­leases GnRH a cou­ple of times a day. This hor­mone then stim­u­lates the re­lease of two other hor­mones in the pi­tu­itary: LH and FSH. These hor­mones in turn are re­spon­si­ble for testos­terone pro­duc­tion in the testes in men and the pro­duc­tion of testos­terone, pro­ges­terone and estra­diol in the ovaries in women. The re­searchers ex­posed GnRH-pro­duc­ing cells to a nor­mal con­cen­tra­tion of glu­cose [5 mil­limoles] [NG], a high con­cen­tra­tion of glu­cose [22 mil­limoles] [HG], a very high con­cen­tra­tion of glu­cose [40 mil­limoles] [VHG] and to the car­bo­hy­drate man­ni­tol in a con­cen­tra­tion of 20 mil­limoles [M]. If your glu­cose and in­sulin reg­u­la­tion is work­ing ok your glu­cose lev­els won’t reach the high lev­els the Ital­ians used in their ex­per­i­ment. Di­a­bet­ics on the other hand may ex­pe­ri­ence these lev­els. And foods con­tain­ing large amounts of rapidly ab­sorbed car­bo­hy­drates can boost healthy people’s glu­cose lev­els to some­where be­tween the nor­mal con­cen­tra­tion [5 mil­limoles] [NG] and the high con­cen­tra­tion [20 mil­limoles] [HG]. The re­sults showed that high con­cen­tra­tions of glu­cose re­duced the re­lease of GnRH. This is prob­a­bly be­cause, in large quan­ti­ties, glu­cose re­duces the pro­duc­tion of the re­cep­tor for the KISS-1 pep­tide as well as the re­lease of KISS-1. KISS-1 is re­ally a hor­mone and it boosts the re­lease of GnRH. A high con­cen­tra­tion of glu­cose also re­duces the man­u­fac­ture of lep­tin [LEPR] re­cep­tors. Lep­tin is a hor­mone re­leased by fat cells. It stim­u­lates the re­lease of LH, and there­fore also testos­terone, via KISS-1. The Ital­ians are not a hun­dred per­cent sure of their find­ings: and there­fore whether what they ob­served in the cells they used is rep­re­sen­ta­tive of what hap­pens to all GnRH-pro­duc­ing cells in the brain. The Ital­ians’ Ital­ians re­search was not funded by a low-carb diet prod­ucts man­u­fac­turer but by the Ital­ian govern­ment.

Ref­er­ence: Int J En­docrinol. 2013;2013:684659. doi: 1

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