WITH­OUT TESTOS­TERONE

Australian Natural Bodz - - Health, Sex & Longevity -

If you’ve got no testos­terone in your body you can’t build up mus­cles, say the text­books. Not so, say sports sci­en­tists at the Univer­sity of Mary­land in the United States. They dis­cov­ered that men with prostate can­cer who are tak­ing drugs that block the ef­fects of testos­terone can still build up mus­cle mass and strength by do­ing strength train­ing. Study Nearly all men, if they live long enough, de­velop prostate can­cer. Doc­tors usu­ally start by treat­ing prostate can­cer with medicines that pre­vent testos­terone or other an­dro­gens from in­ter­act­ing with the an­dro­gen re­cep­tor. They of­ten com­bine the anti-an­dro­gens with other drugs that block the brain’s se­cre­tion of reg­u­la­tory hor­mones such as LH and FSH. With­out those hor­mones the testes don’t pro­duce testos­terone. Anti-an­dro­gen ther­apy in­hibits the growth of many prostate can­cer tu­mours, but side ef­fects in­clude mus­cle mass de­crease, loss of strength, in­creased body­weight and in­creas­ing dif­fi­culty in per­form­ing ev­ery­day ac­tiv­i­ties. The re­searchers wanted to see whether strength train­ing could help change this. The re­searchers per­formed ex­per­i­ments with 17 men all of whom had prostate can­cer, were re­ceiv­ing anti-an­dro­gen ther­apy and, with an av­er­age fat per­cent­age of 31.4%, were over­weight. Their av­er­age age was 67.For a pe­riod of 12 weeks the re­searchers got the men to train three times a week us­ing re­sis­tance ma­chines to ex­er­cise their main mus­cle groups. They did uni­lat­eral knee ex­ten­sions, chest press, seated rows, seated ham­string curls, ab­dom­i­nal crunches and leg presses. Af­ter warm­ing up, the men did 4-5 reps us­ing a weight with which they could just man­age 5 reps. Af­ter that the weight was re­duced and with­out rest­ing they did another 1-2 reps to fail­ure. Af­ter that the weight was re­duced again and they did another 1-2 reps to fail­ure, and so on and so on. For each ex­er­cise the men did a to­tal of 15 reps. Re­sults De­spite the fact that the men had vir­tu­ally no testos­terone in their bod­ies, they still man­aged to build up over 1.5 kg mus­cle mass. Their fat per­cent­age went down from 31.4 per­cent to 30.7 per­cent.Their max­i­mal strength in­creased for knee ex­ten­sions, chest press and leg press. At the end of 12 weeks of do­ing strength train­ing, the men were find­ing ev­ery­day ac­tiv­i­ties eas­ier. They could get up and sit down again on a chair more times in a short time span [Chair Stands], they could climb stairs faster and took less time to cover a dis­tance of 400 me­tres. Strength train­ing im­proved their qual­ity of life. The men’s score for the Brief Fa­tigue In­ven­tory went down – show­ing that they had more energy. In ad­di­tion, the men con­sid­ered that they were func­tion­ing bet­ter so­cially, emo­tion­ally and phys­i­cally. Con­clu­sion “Con­trary to the com­monly ac­cepted role of testos­terone in strength train­ing-in­duced mus­cle hyper­tro­phy and within the lim­i­ta­tions of this study, we present pre­lim­i­nary ev­i­dence that near op­ti­mal mus­cle adap­ta­tions can oc­cur in older hy­pog­o­nadal men”, the re­searchers wrote. “The ob­served gains in mus­cle mass and strength are as­so­ci­ated with im­proved func­tional in­de­pen­dence and qual­ity of life in these men.” “A bet­ter un­der­stand­ing of the mech­a­nisms re­spon­si­ble for the in­creases in mus­cle hyper­tro­phy, strength, and phys­i­cal func­tion in the ab­sence of testos­terone could help pre­vent the mo­bil­ity lim­i­ta­tions, weak­ness, fa­tigue, and poor qual­ity of life com­mon in men with prostate can­cer re­ceiv­ing an­dro­gen de­pri­va­tion ther­apy.”

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