VI­TA­MIN D BOOSTS THE AN­ABOLIC EF­FECT OF AMINO ACID LEUCINE

Australian Natural Bodz - - Supplement Central -

Adding the amino acid leucine to pro­tein-rich meals is per­haps the most ef­fec­tive sup­ple­men­ta­tion strat­egy for strength ath­letes seek­ing to speed up mus­cle growth. Re­searchers at Cler­mont Univer­site in France have dis­cov­ered that the higher the con­cen­tra­tion of vi­ta­min D3 in the blood, the greater the an­abolic ef­fect of leucine. Study The re­searchers ex­posed C2C12 mus­cle cells in test tubes to leucine, in­sulin and vary­ing con­cen­tra­tions of 1,25(OH)2vi­ta­min D3, which also goes by the name of cal­citriol. This is the ac­tive form of vi­ta­min D. The re­searchers also added la­belled va­line to the test tubes, so they could see whether the mus­cle cells built the va­line into their pro­tein struc­tures. This en­abled them to mea­sure the an­abolic ef­fect of the leucine-in­sulin cocktail. The more 1,25(OH)2-vi­ta­min D3 there was in the test tubes, the greater the an­abolic ef­fect. Re­sults When the re­searchers looked closely at the pro­duc­tion and ac­tiv­ity of an­abolic sig­nal pro­teins, they no­ticed that 1,25(OH)2-vi­ta­min D3 made the in­sulin re­cep­tor more sen­si­tive. The greater the con­cen­tra­tion of 1,25(OH)2vi­ta­min D3, the greater the ac­tiv­ity of an­abolic sig­nal pro­teins such as Akt, GSK3, p70-S6K and 4EBP1. The re­searchers re­veal the way in which 1,25(OH)2-vi­ta­min D3 gets the mus­cle cell’s an­abolic ma­chin­ery to work harder. Vi­ta­min D3 in­duces mus­cle cells to man­u­fac­ture more in­sulin re­cep­tors. At the same time the mus­cle cells also pro­duce more vi­ta­min-D re­cep­tors as a re­sult of ex­po­sure to 1,25(OH) 2-vi­ta­min D3, an ef­fect that other re­searchers had al­ready ob­served. [En­docrinol Metab Clin North Am. 2010 Jun;39(2):255-69.] Con­clu­sion “The tran­scrip­tional in­duc­tion of these genes as well as a po­ten­ti­a­tion of the in­sulin and leucine ac­tion on key re­lated pro­teins is likely one of the cen­tral mech­a­nisms of ac­tion of vi­ta­min D on skele­tal mus­cle an­abolism”, the re­searchers write. “Over­all, our data open up per­spec­tives for po­ten­tially valu­able nutri­tional in­ter­ven­tions cou­pling vi­ta­min D and amino acid sup­ple­men­ta­tion, mainly in sit­u­a­tions like sar­cope­nia where vi­ta­min D and amino acid re­sponse is de­fi­cient, to sup­port mus­cle fiber pro­tein syn­the­sis.” Ref­er­ence: Mol Nutr Food Res. 2013 Dec;57(12):2137-46.

Photo by Steve Jones

luke tonegano

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