The Doc Savage of Earth-616?
While Marvel held the Doc Savage licence, it toyed with the idea of folding him firmly into the Marvel Universe. To that end, Doc made co-starring appearances with both SpiderMan and the Thing. In issue #3 of Giant-Size Spider-Man, Spidey encounters a blueskinned alien girl at a demolition site. During the building’s foundation-laying ceremony 40 years earlier, Doc and his aides combat a monstrous energy entity that appears to be trying to kill the very same alien girl. The two heroes never actually meet, and the same is true of the Thing and Doc in Marvel Two-In
One #21, at least for the first 10 pages where their storylines run in parallel as they investigate separate but linked incidents. Then their timelines merge and together they battle Blacksun, a supervillain fused from a father and son, and powered by a black hole.