Amazing Spider-Man #544
Peter Parker might have been happy living in married bliss with Mary Jane Watson, but the fans weren’t so enamoured. It was 2007, a new generation of readers were getting into comics, and to be honest, nobody wanted to read about a guy who’d settled down. So in Amazing Spider-Man #544, the whole thing was annulled. Not because MJ and Peter weren’t getting on, but because otherdimensional ne’er-do-well Mephisto was up to his old tricks again. Aunt May was dying and SpiderMan was powerless, until the devilish rogue offered a choice: Aunt May could live, but he would steal the Parkers’ happiness and reset time so they’d never married.