Amazing spider-man #700
Not content with trying to marry Aunt May back in the day, Doctor Octopus decided in 2013 that he now had designs on Peter Parker’s body. No, not like that. Doc Ock is dying and comes up with a nifty little scheme he puts into action in Amazing Spider-Man #699-700 – he transplants his mind into Peter’s body, and vice-versa, leaving poor old Peter to die in Ock’s failing shell. Given quite literally a new lease of life in SpiderMan’s bod, Ock becomes something of a reformed character and decides to continue to fight crime as Spidey, as detailed in the 31 issues of Superior Spider-Man. He does, of course, dispense with the wise-cracks and ramp up the arrogance to eleven.