Propellerhead Reason (2000)
A logical continuation of the self-contained ReBirth, Reason is a comprehensive electronic music studio full of synths, samplers, mixers and effects that load into a virtual rack, complete with patch cables for signal routing. Once a project is complete, it can be traded with other users in a tidy proprietary file format.
Originally a closed system dedicated solely to sequenced productions, Reason eventually grew into a full-fledge DAW with the addition of audio recording, editing and its own plugin format called Rack Extensions. More recently, Propellerhead have added VST support.