Manga doesn’t just stick to traditional boxes in rows. It often employs dynamic panel layouts that stretch across the height or width of the whole page, along with diagonal lines and irregular shapes. Sometimes boxes aren’t even used at all, with hazy patterns used as outlines, or the character breaks out of the panel. Panels can even fade in and out as part of the storytelling. The difficulty is ensuring that regardless of layout, the panel order remains clear. Try reading some manga to find lots more examples to play with.