Alzheimer’s hope

Pharmacy Daily - - NEWS -

AUS­TRALIAN re­searchers in Mel­bourne and China have used ex­per­i­men­tal drugs to tar­get a re­cently de­scribed molec­u­lar path­way that dam­ages the brain af­ter a stroke, bring­ing these treat­ments one step closer to the clinic for stroke suf­fer­ers.

Us­ing pre-clin­i­cal an­i­mal mod­els of is­chaemic stroke, re­searchers have now shown that the tau pro­tein, which sta­bilises the cel­lu­lar ‘train track’ that trans­ports mol­e­cules around cells, is also in­volved in stroke.

Pub­lished in Molec­u­lar Psy­chi­a­try the study showed that tau lev­els could be pro­tected fol­low­ing a stroke and five dif­fer­ent ex­per­i­men­tal drugs were tri­alled, with fer­rop­to­sis in­hibitors clear win­ners for their ther­a­peu­tic po­ten­tial in the end.

Visit na­ture.com for the study.

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