Final Fantasy 10
At first it seems Yuna has to sacrifice herself to save the world from Sin, but Tidus ends up making the selfless save.
Tales From The Borderlands
Poor Scooter. The poor sap sacrifices himself trying to disengage an unstable rocket booster on the your ship.
Star Wars: The Force Unleashed
Starkiller is a charisma vacuum, but his selfless sacrifice inspires the Rebel Alliance.