THE ESSENTIALS

Western Suburbs Weekly - - Meth Crisis - Cure In The Community -

The GABA re­cep­tors are a class of re­cep­tors that re­spond to the neu­ro­trans­mit­ter gamma-aminobu­tyric acid, the chief in­hibitory com­pound in the ma­ture ver­te­brate cen­tral ner­vous sys­tem.

The re­cep­tors are known as “re­ward cen­tres”, caus­ing plea­sure - or the high as­so­ci­ated with drug use.

GABA-A re­cep­tors are the main fast in­hibitory neu­ro­trans­mit­ter re­cep­tors in the hu­man brain, and tar­gets for many drugs used in the treat­ment of anx­i­ety disor­ders. There are sig­nif­i­cant risks as­so­ci­ated with the long-term use of these drugs par­tic­u­larly re­lated to devel­op­ment of tol­er­ance and ad­dic­tion.

Nal­trex­one blocks the high gen­er­ated by the GABA-A re­cep­tors. Dr O’neil de­vel­oped the nal­trex­one im­plants for heroin ad­dic­tion, but in re­cent years has treated hun­dreds of peo­ple each year for metham­phetamine ad­dic­tion.

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