AT about 9pm on Tuesday night thieves gained entry to Cane Country Tyres on the Bruce Hwy in Proserpine.
Access was gained by cutting a fence and smashing a window before a safe containing cash was stolen.
CCTV footage was taken and can be viewed by visiting mypolice.qld.gov. au/mackay.
Police are urging business owners to review their security.
Anyone with information is asked to contact Crimestoppers.