The couple that just might end COVID-19
Husband-and-wife team behind BioNTech, whose vaccine holds promise
Two years ago, Dr. Ugur Sahin took the stage at a conference in Berlin and made a bold prediction. Speaking to a roomful of infectious disease experts, he said his company might be able to use its so-called messenger RNA technology to rapidly develop a vaccine in the event of a global pandemic.
At the time, Sahin and his company, BioNTech, were little known outside the small world of European biotechnology startups. BioNTech, which Sahin founded with his wife, Dr. Ozlem Tureci, was mostly focused on cancer treatments. It had never brought a product to market.
COVID-19 did not yet exist. But his words proved prophetic.
On Monday, BioNTech and Pfizer announced that a vaccine for the coronavirus developed by Sahin and his team was more than 90 per cent effective in preventing the disease among trial volunteers who had no evidence of having previously been infected. The stunning results vaulted BioNTech and Pfizer to the front of the race to find a cure for a disease that has killed more than 1.3 million people.
“It could be the beginning of the end of the COVID era,” Sahin said in an interview this week.
BioNTech began work on the vaccine in January, after Sahin read an article in the medical journal the Lancet that left him convinced that the coronavirus,
at the time spreading quickly in parts of China, would explode into a full-blown pandemic. Scientists at the company, based in Mainz, Germany, cancelled vacations and set to work on what they called Project Lightspeed.
“There are not too many companies on the planet which have the capacity and the competence to do it so fast as we can do it,” Sahin said in an interview last month. “So it felt not like an opportunity, but a duty to do it, because I realized we could be among the first coming up with a vaccine.”
After BioNTech had identified several promising vaccine candidates, Sahin concluded that the company would need help to rapidly test them, win ap
proval from regulators and bring the best candidate to market. BioNTech and Pfizer had been working together on a flu vaccine since 2018, and in March, they agreed to collaborate on a coronavirus vaccine.
Since then, Sahin, who is Turkish, has developed a friendship with Albert Bourla, the Greek chief executive of Pfizer. The pair said in recent interviews that they had bonded over their shared backgrounds as scientists and immigrants.
Sahin, 55, was born in Iskenderun, Turkey. When he was 4, his family moved to Cologne, Germany, where his parents worked at a Ford factory.
He grew up wanting to be a doctor, and became a physician
at the University of Cologne. In 1993, he earned a doctorate from the university for his work on immunotherapy in tumour cells.
Early in his career, he met Tureci. She had early hopes to become a nun and ultimately wound up studying medicine. Tureci, now 53 and the chief medical officer of BioNTech, was born in Germany, the daughter of a Turkish physician who emigrated from Istanbul. On the day they were married, Sahin and Tureci returned to the lab after the ceremony.
The couple were initially focused on research and teaching, including at the University of Zurich, where Sahin worked in the lab of Rolf Zinkernagel, who won the 1996 Nobel Prize in medicine.
In 2001, Sahin and Tureci founded Ganymed Pharmaceuticals, which developed drugs to treat cancer using monoclonal antibodies.
After several years they founded BioNTech as well, looking to use a wider range of technologies, including messenger RNA, to treat cancer. “We want to build a large European pharmaceutical company,” Sahin said in an interview with the Wiesbaden Courier, a local paper.
Even before the pandemic, BioNTech was gaining momentum. The company raised hundreds of millions of dollars and now has more than1,800 people on staff, with offices in Berlin, other German cities and Cambridge, Mass.
In 2018, it began its partnership with Pfizer. Last year, the Bill & Melinda Gates Foundation invested $55 million (U.S.) to fund its work treating HIV and tuberculosis.
Sahin and Tureci sold Ganymed for $1.4 billion in 2016. Last year, BioNTech sold shares to the public; in recent months, its market value has soared past $21 billion, making the couple among the richest in Germany. The two billionaires live with their teenage daughter in a modest apartment near their office.
BioNTech has been so busy developing a vaccine that the company has not finalized the financial details of its partnership agreement with Pfizer.
“Trust and personal relationship is so important in such business, because everything is going so fast,” Sahin said.