Aus­tralian sci­en­tists a step closer to cre­at­ing HIV vac­cine

China Daily (USA) - - WORLD - By XIN­HUA in Can­berra

Aus­tralian sci­en­tists say they have taken a step in the “right di­rec­tion” to­ward cre­at­ing a vac­cine for HIV.

Re­searchers­fromSouthAus­tralia’s Univer­sity of Ade­laide and the Queen El­iz­a­beth Hos­pi­tal have used a com­mon cold virus to in­tro­duce their DNAbased vac­cine into the im­mune sys­tem of lab­o­ra­tory mice.

Dr Branka Gru­bor-Bauk from the Univer­sity of Ade­laide said the team tar­geted the vac­cine in ar­eas in which the HIV in­fec­tion is most com­monly found, and dis­cov­ered that the test­ing achieved a “sig­nif­i­cant re­duc­tion” of in­fec­tion rates in the mice.

“You need to get protection where your body en­coun­ters the virus first and you need to stop that virus from ei­ther en­ter­ing, or you need to stop it from repli­cat­ing and stop it from spread­ing,” Gru­bor-Bauk told the Aus­tralian Broad­cast­ing Corp onMon­day.

“We’re hop­ing our dis­cov­ery is def­i­nitely point­ing us in the right di­rec­tion.”

She said it was vi­tal that the re­search con­tin­ued.

“After a long four years of study, we were able to cre­ate this com­mon cold virus that en­coded pro­teins of HIV and we vac­ci­nated mice and we were suc­cess­ful in cre­at­ing im­mu­nity in mu­cosal sur­faces,” Gru­bor-Bauk said.

“That’s one of the most dif­fi­cult things re­searchers can do in vac­cine re­search for HIV.”

She con­tin­ued: “We’re hop­ing to get more fund­ing to take this re­search fur­ther be­forewe can im­ple­ment phase-1 clin­i­cal tri­als.

“We al­so­have aDNA­vac­cine we ad­min­is­tered in­tra­der­mally, like the in­fluenza vac­cine, and we found by ad­min­is­ter­ing this vac­cine we were able to get a sys­temic im­mu­nity through­out the body.”

The re­sults of the test­ing were pub­lished in the Sci­en­tific Re­ports jour­nal.

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