基于 SF-36量表的加减毓麟汤改善卵巢早衰脾肾阳虚证患者生活质量临床评价

CJI (Traditional Chinese Medicine) - - News -

滕秀香1,李培培 2,姚海洋 1,苑晶晶 1

1.首都医科大学附属北京中医医院,北京 100010;2.宁波市第七医院,浙江 宁波 315202摘要:目的 观察加减毓麟汤对卵巢早衰脾肾阳虚证患者生活质量的改善作用。方法 将 127 例患者采用小样本病例非随机非劣效性对照研究方法分为试验组80例和对照组47例。试验组予加减毓麟汤,每日1剂,

早晚分服;对照组口服戊酸雌二醇片加黄体酮人工周期治疗。2组均连续用药21 d,疗程间隔 5d。3 个用药周期为 1个疗程,共治疗2个疗程。治疗前后采用 SF-36 量表计算8个维度得分及总分。结果 治疗前2 组 SF-36

量表各维度(除躯体疼痛)评分及总分比较,差异无统计学意义(P>0.05)。与治疗前比较,试验组SF-36 量

表各维度评分及总分提高(P<0.05,P<0.01)。对照组总分、精神健康评分提高(P<0.05,P<0.01)。治疗后 2组活力、精神健康2个维度比较,差异有统计学意义(P<0.05)。治疗后2 组 SF-36 量表总分差值及生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康7个维度评分差值比较,差异有统计学意

义(P<0.01)。结论 加减毓麟汤可改善卵巢早衰脾肾阳虚证患者生活质量。

关键词:卵巢早衰;脾肾阳虚;加减毓麟汤;生活质量;SF-36量表

DOI:10.3969/j.issn.1005-5304.2017.03.007

中图分类号:R271.917.5 文献标识码:A 文章编号:1005-5304(2017)03-0026-04

Clinical Evaluation on Improving Living Quality of Patients with Yang-deficiency of Spleen and Kidney of Premature Ovarian Failure with Modified Yulin Decoction Based on SF-36 Scale

TENG Xiu-xiang1, LI Pei-pei2, YAO Hai-yang1, YUAN Jing-jing1 (1. Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100010, China; 2. Ningbo NO.7 Hospital, Ningbo 315202, China)

Abstract: Objective To observe the effect of the modified Yulin Decoction on improving the living quality of patients with yang-deficiency of the spleen and kidney of premature ovarian failure. Methods One hundred and twenty-seven patients were divided into experimental group (80) and control group (47) by non-randomized noninferiority comparative study. The experimental group was treated with modified Yulin Decoction daily orally once a day. The control group was treated with oral estradiol valerate and progesterone cycle. Two groups received continuous medication for 21 d, and treatment interval was 5 d. Three cycles of treatment were set as one course, and treated for 2 courses. The SF-36 scale was used to calculate the total scores and scores of eight dimensions before and after treatment. Results Before treatment, there was no significant difference (P>0.05) in the scores of SF-36 dimensions (except somatic pain) and total score between the two groups. Compared with before treatment, the score and total score of SF-36 in the experimental group increased (P<0.05, P<0.01). The mental health score of the control group was higher than that of before treatment (P<0.05, P<0.01). After treatment, there was statistical significance in the two dimensions of vitality and mental health in the two groups (P<0.05). There were significant differences (P<0.01) in the total score and scores of SF-36 physiological function, physical pain, general health, vigor, social function, emotional function and mental health between the two groups. Conclusion Modified Yulin Decoction can improve the living quality of patients with yang-deficiency of the spleen and kidney of premature ovarian failure.

Key words: premature ovarian failure; yang-deficiency of the spleen and kidney; modified Yulin Decoction; living quality; SF-36 scale

基金项目:北京市科委“首都临床特色应用研究”项目(Z131107002213138);北京市卫生系统高层次卫生技术人才培养计划

专项(2013-2-028)

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