Sci­en­tific ex­perts cre­ate first nanopar­ti­cle-based tis­sue ad­he­sive

BioSpectrum (Asia) - - Science News -

Re­searchers at the Cen­ter for Nanopar­ti­cle Re­search, within the In­sti­tute for Ba­sic Science (IBS) in col­lab­o­ra­tion with med­i­cal doc­tors in Seoul Na­tional Univer­sity Hospi­tal, created a sur­gi­cal glue that is both ad­her­ent and vis­i­ble in the most com­mon imag­ing tech­niques: flu­o­roscopy, ul­tra­sound, and com­puted to­mog­ra­phy (CT). It is the first nanopar­ti­cle-based tis­sue ad­he­sive that fea­tures these char­ac­ter­is­tics. Its prop­er­ties were suc­cess­fully tested in seal­ing a liver punc­ture and in con­duct­ing op­er­a­tions in mov­ing or­gans, like lung and limbs. IBS sci­en­tists in col­lab­o­ra­tion with re­searchers at Kook­min Univer­sity and Seoul Na­tional Univer­sity Hospi­tal de­signed nanopar­ti­cles with a shell made of sil­ica (SiO2) and a core of ra­diopaque tan­ta­lum ox­ide (TaOx). SiO2 holds the tis­sue to­gether, while TaOx pro­vides con­trast enhancement on ul­tra­sound and CT. The re­search team tested the TaOx/SiO2 core/shell nanopar­ti­cle (TSN) glue and found that it is clearly vi­su­al­ized by real-time imag­ing modal­i­ties and ex­hibits ad­he­sive prop­er­ties sim­i­lar to that of the U.S. Food and Drug Ad­min­is­tra­tion (FDA)-ap­proved cyanoacry­late and Li­p­i­odol (CA-Lp), a mix­ture of a tis­sue ad­he­sive and ra­diopaque oil used in the clin­i­cal prac­tice. This is im­por­tant be­cause it could help sur­geons to rec­og­nize a mov­ing sur­gi­cal tar­get and per­form a safe and ac­cu­rate op­er­a­tion.

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