Singapore researchers develop gel patch for healing purpose
Scientists from Nanyang Technological University, Singapore (NTU, Singapore) have developed a new gel patch prototype that could speed up the healing of a skin wound while minimizing the formation of scars.
When fully developed, this healing patch could be a boon for diabetic patients, who suffer from hard-to-heal skin lesions and for patients undergoing surgery. The new patch is unlike other singlepurpose patches in the market, which either reduce the scarring or improve healing, but not both.
The team found that a protein known as Angiopoietin-like 4 (ANGPTL4) reduces inflammation in the early phase of wound healing in mice models. Later, it helps in the formation of new blood vessels and cell growth, and at the final phase, reduces scarring. The team developed their patch enriched with ANGPTL4 to control the amount of scarring. NTU already has a patent on the use of Angiopoietinlike 4 (ANGPTL4) in wound healing, which can be licensed to pharmaceutical companies. The research team will further refine the gel formulation to improve its efficacy, before conducting further lab trials and eventually moving into clinical trials.