Sin­ga­pore re­searchers de­velop gel patch for heal­ing pur­pose

BioSpectrum (Asia) - - Science News -

Sci­en­tists from Nanyang Tech­no­log­i­cal Univer­sity, Sin­ga­pore (NTU, Sin­ga­pore) have de­vel­oped a new gel patch pro­to­type that could speed up the heal­ing of a skin wound while min­i­miz­ing the for­ma­tion of scars.

When fully de­vel­oped, this heal­ing patch could be a boon for di­a­betic pa­tients, who suf­fer from hard-to-heal skin le­sions and for pa­tients un­der­go­ing surgery. The new patch is un­like other sin­glepur­pose patches in the mar­ket, which either re­duce the scar­ring or im­prove heal­ing, but not both.

The team found that a pro­tein known as An­giopoi­etin-like 4 (ANGPTL4) re­duces in­flam­ma­tion in the early phase of wound heal­ing in mice mod­els. Later, it helps in the for­ma­tion of new blood ves­sels and cell growth, and at the fi­nal phase, re­duces scar­ring. The team de­vel­oped their patch en­riched with ANGPTL4 to con­trol the amount of scar­ring. NTU al­ready has a patent on the use of An­giopoi­etinlike 4 (ANGPTL4) in wound heal­ing, which can be li­censed to phar­ma­ceu­ti­cal com­pa­nies. The re­search team will fur­ther re­fine the gel for­mu­la­tion to im­prove its ef­fi­cacy, be­fore con­duct­ing fur­ther lab tri­als and even­tu­ally mov­ing into clin­i­cal tri­als.

Newspapers in English

Newspapers from India

© PressReader. All rights reserved.