CANbridge Life Sciences to begin CAN017 Ib/III Trial in China
CANbridge Life Sciences, a biopharmaceutical company developing western drug candidates in China and North Asia, has announced that the China National Drug Administration (CNDA) has approved the Investigational New Drug (IND) application for a Phase Ib/III clinical study of CAN017 in esophageal squamous cell cancer (ESCC).
The Phase Ib/extension study is a multicentre, open label study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of CAN017 in combination with chemotherapy as the second line treatment for patients with locally advanced or metastatic esophageal squamous cell carcinoma (ESCC). ESCC is the most prevalent form of esophageal cancer, with 50 per cent of the cases occurring in China.
The CAN017 IND approval is a key milestone for CANbridge and the second one this year, following the IND approval to commence a trial in CAN008 in glioblastoma multiforme (GBM) in April. CAN017 is an ErbB3 (HER3) inhibitory antibody humanized IgG1/κ ERBB3 inhibitory antibody that completed a first-in-human Phase I clinical trial in patients with advanced solid tumors in US patients.