Sci­en­tists de­velop bio­ma­te­rial for faster blood clot­ting

BioSpectrum (India) - - SCIENCE NEWS -

In­dian sci­en­tists have devel­oped a na­ture-in­spired bio­ma­te­rial with en­hanced blood clot­ting ef­fi­ciency to treat in­juries. The new ma­te­rial has been devel­oped by sci­en­tists at In­dian In­sti­tute of Sci­ence Ed­u­ca­tion and Re­search, Kolkata (IISER-K) and Saha In­sti­tute of Nu­clear Physics, Kolkata. Re­searchers have mod­i­fied nat­u­ral bio­ma­te­ri­als, pep­tides, to de­velop sealants with im­proved strength, sta­bil­ity and clot­ting prop­er­ties.

Com­puter based analy­ses was em­ployed, us­ing var­i­ous ap­proaches, to gen­er­ate sealant struc­tures with de­sired prop­er­ties. These struc­tures were then syn­the­sized and eval­u­ated un­der lab­o­ra­tory con­di­tions.

These tests re­vealed that the en­gi­neered sealant was able to self­assem­ble, much like hu­man body’s nat­u­ral clot­ting mech­a­nism, to form an in­ter­wo­ven struc­ture re­sem­bling a clot but in nearly half the time. This en­hanced clot­ting rate can play an ex­tremely cru­cial role in treat­ing in­juries sus­tained dur­ing ac­ci­dents or mil­i­tary com­bat. The nat­u­ral ma­te­rial of the en­gi­neered sealant will en­sure that it is tol­er­ated by the body with min­i­mal in­flam­ma­tory re­sponse. It is also bio-degrad­able, sim­i­lar to the nat­u­ral clot­ting fac­tor.

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