IIT- Guwa­hati re­searchers make im­plantable pan­creas

BioSpectrum (India) - - SCIENCE NEWS -

Re­searchers at the In­dian In­sti­tute of Tech­nol­ogy (IIT) Guwa­hati have suc­cess­fully cre­ated an im­plantable bioar­ti­fi­cial pan­creas model grown within a 3D silk scaf­fold. The “pan­creas”, which en­cap­su­lates in­sulin-pro­duc­ing cells, is ca­pa­ble of nat­u­rally pro­duc­ing in­sulin in a sus­tained man­ner. The silk scaf­fold was found to be bio­com­pat­i­ble

(not toxic to liv­ing tis­sue) as it did not trig­ger any im­mune re­ac­tion or cause any ad­verse re­ac­tion when im­planted.

Since type 1 di­a­betes pa­tients do not have in­sulin-pro­duc­ing beta cells, the re­searchers have turned to stem cells to pro­duce beta cells. The team coated the scaf­fold con­tain­ing beta cells with a semi-per­me­able mem­brane bar­rier. The mem­brane al­lows in­sulin pro­duced to be re­leased into the blood stream but does not al­low the im­mune cells to cross the mem­brane and kill the islet cells. To en­sure that the im­plant is not re­jected by the body’s im­mune sys­tem, drugs that sup­press the im­mune sys­tem were em­bed­ded in the scaf­fold. The re­searchers are plan­ning to carry out tri­als in an­i­mals. If suc­cess­ful in an­i­mal and hu­man tri­als, it can be used for treat­ing peo­ple with type 1 di­a­betes.

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