Kolkata re­searchers de­sign drug nanocar­ri­ers

BioSpectrum (India) - - SCIENCE NEWS -

A group of re­searchers from CSIR-In­dian In­sti­tute of Chem­i­cal Bi­ol­ogy, Kolkata, has de­signed an ef­fi­cient drug nanocar­rier us­ing gold nanopar­ti­cles coated with a sim­ple or­ganic mol­e­cule (por­phyrin). The nanocar­rier was found to ef­fec­tively de­liver the anti-tu­mour drug dox­oru­bicin anti-tu­mour drug to the nu­cleus of the dis­eased cell and bring about pro­grammed cell death. The por­phyrin mol­e­cule was found to be uni­formly dis­trib­uted on gold nanopar­ti­cles and the por­phyrin–gold com­plex was sta­ble. The com­plex with­out the drug showed no tox­i­c­ity to healthy and can­cer­ous cells. Mul­tidrug re­sis­tance is one of the ma­jor bar­ri­ers in can­cer cells, where the drug is quickly ejected out, re­duc­ing the ef­fec­tive drug con­cen­tra­tions within the cells and thus de­creases its sensitivity. The re­searchers are cur­rently study­ing the path­ways by which drugs can dam­age the DNA, and try­ing to de­sign a sys­tem that can re­lease the drug more ef­fi­ciently.

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