Re­searchers de­velop sen­si­tive di­ag­nos­tic test for TB menin­gi­tis

BioSpectrum (India) - - SCIENCE NEWS -

A team of re­searchers from All In­dia In­sti­tute of Med­i­cal Sci­ences (AIIMS), New Delhi and Trans­la­tional Health Sci­ence and Tech­nol­ogy In­sti­tute (THSTI), Farid­abad has de­vel­oped a di­ag­nos­tic test for TB menin­gi­tis with nearly 100 per cent sen­si­tiv­ity and about 91 per cent speci­ficity. The di­ag­nos­tic test is based on a de­riv­a­tive of a DNA ap­tamer that is a small sin­gle-stranded DNA mol­e­cule that binds to a spe­cific tar­get mol­e­cule and is a chem­i­cal ri­val of an­ti­bod­ies. The de­riv­a­tive shows high bind­ing affin­ity in nanomo­lar range and high speci­ficity to a TB anti­gen (HspX). Be­sides higher bind­ing affin­ity, there is sig­nif­i­cantly higher load of the HspX anti­gen in cere­brospinal fluid sam­ples, lead­ing to higher sen­si­tiv­ity. The ap­tamer-based di­ag­nos­tic test for TB menin­gi­tis has been patented by AIIMS and THSTI and li­censed to Ap­taBharat In­no­va­tion Pvt Lim­ited, a THSTI spinoff founded by Dr Tarun Ku­mar Sharma, Cen­tre for Biode­sign and Di­ag­nos­tics at THSTI.

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