Pune sci­en­tists use nanovesi­cles for im­proved cancer drug delivery

BioSpectrum (India) - - SCIENCE NEWS -

Re­searchers at the In­dian In­sti­tute of Sci­ence Ed­u­ca­tion and Re­search (IISER), Pune have been able to in­crease the up­take of an­ti­cancer drug Alis­ertib by breast cancer cells and achieve greater abil­ity to re­strict cancer cell growth. The re­searchers en­cap­su­lated the poorly wa­ter-sol­u­ble an­ti­cancer drug Alis­ertib in polysac­cha­ride nano-sized balls or vesi­cles. Bet­ter up­take of the drug when en­cap­su­lated meant lower con­cen­tra­tion of the drug was suf­fi­cient to re­strict cancer growth sig­nif­i­cantly bet­ter than the free drug. Ac­cord­ing to the re­searchers, nanovesi­cles with the drugs loaded be­come wa­ter dis­persible thus in­creas­ing the up­take by cancer cells. The team is cur­rently work­ing to make the nanovesi­cles even more spe­cific to cancer cells. The drug-loaded nanovesi­cles are cleaved by es­terase en­zyme once in­side the cell. In spite of be­ing cleaved, the drug is re­leased slowly in a con­trolled man­ner over 8-10 hours.

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