Sci­en­tists cre­ate plat­form to carry out liq­uid biopsy

BioSpectrum (India) - - WORLD NEWS -

Sci­en­tists from Duke Univer­sity, Mas­sachusetts In­sti­tute of Tech­nol­ogy (MIT) and Sin­ga­pore based Nanyang Tech­no­log­i­cal Univer­sity have found that a mi­croflu­idic plat­form based on sound waves can rapidly carry out liq­uid biop­sies. The study showed that the tech­nol­ogy can sep­a­rate cir­cu­lat­ing tu­mour cells (CTCs) from 7.5ml of a blood sam­ple with at least an 86 per cent ef­fi­ciency within one hour. Fast and ef­fi­cient ex­trac­tion of CTCs and their growth is ex­pected to en­able a liq­uid biopsy that can as­sess in­di­vid­ual CTC pro­fil­ing to fa­cil­i­tate di­ag­no­sis, prog­no­sis and treat­ment de­ci­sions. Ac­cord­ing to the sci­en­tists, the risk of dam­age to CTCs is de­creased with the new ap­proach be­cause each tu­mour cell is ex­posed to the sound waves only for a frac­tion of a sec­ond. The sound waves also elim­i­nate the need for la­belling or sur­face mod­i­fi­ca­tion, al­low­ing re­tain­ing of nat­u­ral func­tions and states of the cells. Cur­rently, the teams are work­ing to­wards fur­ther de­vel­op­ing the tech­nol­ogy to en­hance its speed and ef­fi­ciency, while de­ter­min­ing its fea­si­bil­ity in var­i­ous cul­tur­ing and pro­fil­ing projects to val­i­date its clin­i­cal use.

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