Most can­cer due to bad luck

Down to Earth - - SCIENCE - US SCI­EN­TISTS

have cre­ated a sta­tis­ti­cal model that mea­sures the pro­por­tion of can­cer in­ci­dence, across many tis­sue types, caused mainly by ran­dom mu­ta­tions that oc­cur when stem cells divide. By their mea­sure, two-thirds of adult can­cer in­ci­dence are pri­mar­ily due to "bad luck," when th­ese ran­dom mu­ta­tions oc­cur in genes that drive can­cer growth, while the re­main­ing third are due to en­vi­ron­men­tal fac­tors and in­her­ited genes. Science, Jan­uary 2

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