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IVF India - - Chennai, Tamilnadu -

IN­TRA­CY­TO­PLAS­MIC MOR­PHO­LOG­I­CALLY SE­LECTED SPERM IN­JEC­TION (IMSI )

A new com­puter As­sisted tech­nique to iden­tify mor­pho­log­i­cally nor­mal struc­ture for pa­tients with ab­nor­mal sperms. IMSI is based on se­lect­ing the best sperm un­der a mag­ni­fi­ca­tion of more than 6000x. Us­ing this mag­ni­fi­ca­tion mor­pho­log­i­cal de­fects, even small vac­uoles be­come ap­par­ent.

The tech­nique is harm­less and safe and leads to bet­ter em­bryo de­vel­op­ment, higher preg­nancy rates and lower mis­car­riage rates. This is a real boon for pa­tients with re­peated IVF fail­ures and those with re­cur­rent mis­car­riages. In­tra­cy­to­plas­mic Mor­pho­log­i­cally se­lected Sperm In­jec­tion (IMSI ) is con­sid­ered by some ex­perts an ef­fec­tive treat­ment for male fac­tor In­fer­til­ity. The tech­nique in­volves se­lect­ing the best qual­ity sperm cells from the pre­pared se­men sam­ple by ex­am­in­ing un­der a high mag­ni­fi­ca­tion mi­cro­scope which is about 7000 times more pow­er­ful than the stan­dard mi­cro­scope. Ex­plor­ing at this mag­ni­fi­ca­tion shows de­fects in sperm heads, shapes and size and any ab­nor­mal­i­ties as­so­ci­ated with high DNAfrag­men­ta­tion, which can­not be seen with the con­ven­tional mi­cro­scope used for ICSI. The dig­i­tal im­age pro­cess­ing pro­vides ad­di­tional im­age en­hance­ment (over 6000 time) for de­tail recog­ni­tion by the op­er­a­tor. The IMSI will be use­ful for pa­tients who have had re­peated ICSI fail­ers, very low sperm count and large num­bers of ab­nor­mals.

The tech­nique of IMSI was de­vel­oped by Prof. BARTOOV – of IS­RAEL in 2002. He and his team con­ducted a re­search to see which mor­pho­log­i­cal char­ac­ter of sperm af­fected the out­come of ICSI preg­nancy and showed that there was a sig­nif­i­cant im­prove­ment in im­plan­ta­tion, preg­nancy and birth rates us­ing IMSI in patents with 2 or more un­suc­cess­ful ICSI cy­cles.

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