What Causes Bone Loss Among Elderly People
Researchers have identified a mechanism that leads to bone loss in older adults, an advance that may help develop therapeutics to treat the age-associated bone loss condition. Osteoporosis is a major health problem in older people. The findings showed when this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.
The study led by Yi-Ping Li, Professor at the University of Alabama at Birmingham, found a protein called Cbf-beta which plays a critical role in maintaining the bone-producing cells. Furthermore, the examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells as compared to younger mice. The results were published in the journal Proceedings of the National Academy of Sciences.