What Causes Bone Loss Among El­derly Peo­ple

The Day After - - COFFEE HOUSE -

Re­searchers have iden­ti­fied a mech­a­nism that leads to bone loss in older adults, an ad­vance that may help de­velop ther­a­peu­tics to treat the age-as­so­ci­ated bone loss con­di­tion. Os­teo­poro­sis is a ma­jor health prob­lem in older peo­ple. The find­ings showed when this mech­a­nism mal­func­tions, pro­gen­i­tor cells stop cre­at­ing bone-pro­duc­ing cells and in­stead cre­ate fat cells.

The study led by Yi-Ping Li, Pro­fes­sor at the Univer­sity of Alabama at Birm­ing­ham, found a pro­tein called Cbf-beta which plays a crit­i­cal role in main­tain­ing the bone-pro­duc­ing cells. Fur­ther­more, the ex­am­i­na­tion of aged mice showed dra­mat­i­cally re­duced lev­els of Cbf-beta in bone mar­row cells as com­pared to younger mice. The re­sults were pub­lished in the jour­nal Pro­ceed­ings of the Na­tional Academy of Sci­ences.

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