Statin, BP Drug Cut Heart At­tack Risk

The Economic Times - - Around The World -

Pa­tients with high blood pres­sure and mod­er­ate risk of heart dis­ease slashed their long-term risk of heart at­tack and stroke 40% by tak­ing a blood pres­sure med­i­ca­tion as well as a statin choles­terol fighter, ac­cord­ing to a large global study that could change med­i­cal prac­tice.

Re­sults from the trial, called HOPE-3, could prod far more doc­tors to add a statin to blood pres­sure ther­apy for such pa­tients who have no prior his­tory of heart at­tack or stroke, re­searchers said. T he d at a was pr e s ente d on Satur­day at the an­nual sci­en­tific ses­sions of the Amer­i­can Col­lege of Car­di­ol­ogy in Chicago.

To en­roll in the trial, pa­tients had to have at least one risk fac­tor for heart dis­ease such as obe­sity or smok­ing, in ad­di­tion to be­ing over 60 for women and over 55 for men. “In­ter­me­di­ate-risk peo­ple with hy­per­ten­sion had a clear ben­e­fit when tak­ing both a statin and an agent that low­ers blood pres­sure,” Dr Salim Yusuf, a pro­fes­sor of car­di­ol­ogy at McMaster Univer­sity in On­tario, Canada who headed the 12,0 0 0 -pa­tient global study, said in an in­ter­view.

Pa­tients with sys­tolic blood pres­sure of 140 and higher were deemed in the study to have high blood pres­sure. They ex­pe­ri­enced a 40% re­duced risk of heart at­tack and stroke over a six-year pe­riod when tak­ing As­traZeneca’s Crestor statin as well as a com­bi­na­tion tablet con­tain­ing blood pres­sure treat­ment can­desar­tan and the di­uretic hy­drochloroth­iazide.

To en­roll in the trial, pa­tients had to have at least one risk fac­tor for heart dis­ease such as obe­sity or smok­ing

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