Statin, BP Drug Cut Heart Attack Risk
Patients with high blood pressure and moderate risk of heart disease slashed their long-term risk of heart attack and stroke 40% by taking a blood pressure medication as well as a statin cholesterol fighter, according to a large global study that could change medical practice.
Results from the trial, called HOPE-3, could prod far more doctors to add a statin to blood pressure therapy for such patients who have no prior history of heart attack or stroke, researchers said. T he d at a was pr e s ente d on Saturday at the annual scientific sessions of the American College of Cardiology in Chicago.
To enroll in the trial, patients had to have at least one risk factor for heart disease such as obesity or smoking, in addition to being over 60 for women and over 55 for men. “Intermediate-risk people with hypertension had a clear benefit when taking both a statin and an agent that lowers blood pressure,” Dr Salim Yusuf, a professor of cardiology at McMaster University in Ontario, Canada who headed the 12,0 0 0 -patient global study, said in an interview.
Patients with systolic blood pressure of 140 and higher were deemed in the study to have high blood pressure. They experienced a 40% reduced risk of heart attack and stroke over a six-year period when taking AstraZeneca’s Crestor statin as well as a combination tablet containing blood pressure treatment candesartan and the diuretic hydrochlorothiazide.
To enroll in the trial, patients had to have at least one risk factor for heart disease such as obesity or smoking