Prostate cancer spit test starts early trial

Iran Daily - - Health -

Aspit test to de­tect men at in­creased risk of prostate cancer has started early tri­als. The new DNA test looks for high-risk genes that are thought to af­fect one in ev­ery 100 men, BBC re­ported.

Three hun­dred men are tak­ing part in the tri­als, from three Lon­don GP surg­eries.

De­vel­op­ing bet­ter di­ag­nos­tic tests that could be used as part of a na­tion­wide screen­ing pro­gram­mer is a re­search pri­or­ity for prostate cancer.

At present, there is no sin­gle, re­li­able test for prostate cancer. The PSA blood test, biop­sies and phys­i­cal ex­am­i­na­tions are all used.

But the PSA can give false pos­i­tives and sometimes misses more ag­gres­sive cases.

The new DNA test was created by a group of in­ter­na­tional sci­en­tists based at the In­sti­tute of Cancer Re­search (ICR) in Lon­don.

They stud­ied more than 140,000 men and iden­ti­fied 63 new ge­netic vari­a­tions that can in­crease the risk of prostate cancer.

The DNA test com­bines those vari­ants with more than 100 oth­ers pre­vi­ously linked to prostate cancer.

Ros Elees, pro­fes­sor of onco­ge­net­ics at the ICR, said the study was ‘very sig­nif­i­cant’. could ul­ti­mately be em­ployed in the de­sign of new treat­ments”.

The study — pub­lished in the jour­nal Na­ture Ge­net­ics — was funded by the Na­tional Cancer In­sti­tute in the US, with ad­di­tional sup­port from the Euro­pean Re­search Coun­cil, Cancer Re­search UK and Prostate Cancer UK.

Dr. Iain Frame, di­rec­tor of re­search at Prostate Cancer UK said, “This new re­search could help men to un­der­stand their in­di­vid­ual ge­netic risk of prostate cancer, which could prompt them to speak to their GP about the dis­ease.

“Given that one in eight men will be di­ag­nosed with prostate cancer in their life­time, we ur­gently need more ac­cu­rate di­ag­nos­tic tests which are suit­able for use in a na­tion­wide screen­ing pro­gram­mer.”

Carl Alexan­der from Cancer Re­search UK, said the study was ‘an ex­cit­ing ex­am­ple’ of how re­search can find clues in our genes to help us un­cover those more likely to de­velop the dis­ease.

“The next steps should be to un­der­stand how this re­search can be de­vel­oped into tests which could iden­tify men who might be more likely to de­velop ag­gres­sive can­cers, and how this could be rolled out to pa­tients.”

Newspapers in English

Newspapers from Iran

© PressReader. All rights reserved.