Inject-able AIDS drug may work as well as pills: Study
A two-drug cocktail injected every month or two may be just as effective as a daily pill at keeping the AIDS virus under control, said a study yesterday that promised relief for millions. At present people have no option but to take lifelong, daily doses of anti-retroviral therapy (ART) which keeps the HIV virus under control, but does not kill it. People who forget to take their medication run the risk of the virus rebounding to make them ill, or developing resistance to the drugs they were using-which would require a more expensive replacement.
In an ongoing study, nearly 300 HIV-positive people were given an initial course of daily pills to bring the virus under control. Once this was achieved, some continued taking oral treatment as maintenance while the rest were shifted onto the prototype, injectable ARV, administered every four or eight weeks. At 96 weeks, the virus was still subdued in 84 percent of the pill-taking group, 87 percent in the fourweekly injectable group, and 94 percent in the eight-weekly group.
The results were published in The Lancet medical journal to coincide with an HIV science conference in Paris of the International AIDS Society. In 2016, there were some 36.7 million people living with HIV of whom 19.5 million had access to ART, according to UNAIS. The UN recommends ART for all HIV-positive people.
“The introduction of singletablet medication represented a leap forward in ART dosing, and long-active anti-retroviral injections may represent the next revolution in HIV therapy by providing an option that circumvents the burden of daily dosing,” said study co-author David Margo lis of Vi Iv Healthcare, a pharmaceutical company involved in developing the injectable drug. “Adherence to medication remains an important challenge in HIV treatment.”
Also involved in the study is Janssen Sciences, a company in the Johnson & Johnson group.
Last week, the UN warned that countries must halt the rise of AIDS drug resistance to prevent a swell in new infections and deaths and spiraling treatment costs.
WASHINGTON: This file photo shows Dr Ray Martins, chief medical officer at the Whitman-Walker Clinic in Washington, DC, holding a handful of Truvada, the first pill recommended for HIV prevention in healthy people who are at high risk of getting HIV through unprotected sex, or who inject illicit drugs.