Half-time substitute Morata and Luiz reduced the arrears in the second half, either side of Fabregas’s 81st-minute dismissal for a second yellow card, but Burnley hung on for a famous victory.
Liverpool were denied a winning start as Miguel Britos claimed a contentious stoppagetime leveller to earn Watford a 33 draw at Vicarage Road.
Watford twice went in front through Stefano Okaka and Abdoulaye Doucoure, but Liverpool equalised each time via Sadio Mane and Roberto Firmino, who then teed up new boy Mohamed Salah to put the Reds 3-2 up.
In the third minute of injury time, a shot from Richarlison was pushed against the bar by Liverpool goalkeeper Simon Mignolet and Britos, who appeared to be offside, nodded the ball over the line.
“The equaliser was offside. It’s obvious because the linesman is on the line. He needs to see it,” said Liverpool manager Jurgen Klopp.
“We would have had defensive areas we need to work on even if we’d won 3-2, but we were the better team. We should have won.”
Frank de Boer made a losing start to life as Palace manager after a Joel Ward own goal and a Steve Mounie double earned Huddersfield a 3-0 win on their return to the top flight after an absence of 45 years.
Mounie’s goals were the first repayments on his club-record £11.4 million transfer from Montpellier and sent David Wagner’s men to the top of the fledgling standings.
Rooney crowned his first appearance for formative club Everton since 2004 by notching the only goal against Stoke, heading in Dominic Calvert-Lewin’s cross for his 199th Premier League goal.
Debutant Ahmed Hegazi’s first-half header earned West Bromwich Albion a 1-0 win over Bournemouth, while Mauricio Pellegrino’s tenure as Southampton manager began with a 0-0 draw at home to Swansea City.
Late goals from substitutes Aaron Ramsey and Olivier Giroud earned Arsenal a 4-3 win over Leicester in Friday’s frantic opening game. AFP
Chelsea’s Gary Cahill (right) is shown a red card by referee Craig Pawson after a foul on Burnley’s Steven Defour in their Premier League match at Stamford Bridge yesterday.