Con­nec­tion found be­tween os­teo­poro­sis and risk of de­men­tia

The Borneo Post - Nature and health - - Diet -

NEW RE­SEARCH has found that men and women who have os­teo­poro­sis, a con­di­tion which weak­ens bones and makes them more likely to break, may also have an in­creased risk of de­men­tia. Car­ried out by re­searchers at IQVIA and Nord­west Hos­pi­tal, Ger­many and the Univer­sity of Paris, France, the new study set out to look at the as­so­ci­a­tion be­tween os­teo­poro­sis and the risk of de­vel­op­ing de­men­tia in a large Euro­pean pop­u­la­tion, as most re­cent stud­ies have been con­ducted out­side of Europe.

The re­searchers gath­ered data from 29,983 pa­tients di­ag­nosed with os­teo­poro­sis and 29,983 con­trol par­tic­i­pants with­out the con­di­tion but who were matched based on fac­tors such as age and gen­der. Af­ter fol­low- ing the par­tic­i­pants for up to 20 years, the re­searchers found that 20.5 per cent of women with os­teo­poro­sis and 16.4 per cent of the con­trol par­tic­i­pants had been di­ag­nosed with de­men­tia. For men, 22 per cent of those os­teo­poro­sis went on to de­velop de­men­tia com­pared to 14.9 per cent of the con­trols.

The re­searchers con­cluded that there was a pos­i­tive as­so­ci­a­tion be­tween os­teo­poro­sis and de­men­tia, with the con­di­tion as­so­ci­ated with a 1.2-fold in­crease in the risk of be­ing di­ag­nosed with de­men­tia in women and a 1.3-fold in­crease in the risk of be­ing di­ag­nosed with de­men­tia in men.

“There is big in­ter­est in the re­la­tion­ship be­tween os- teo­poro­sis and de­men­tia,” ex­plained lead in­ves­ti­ga­tor Pro­fes­sor Karel Kostev. “This study is the first to ad­dress this ques­tion in a very large data­base en­abling the case-con­trol-com­par­i­son be­tween pa­tients with and with­out os­teo­poro­sis.”

“The ma­jor hy­poth­e­sis to ex­plain the as­so­ci­a­tion be­tween os­teo­poro­sis and de­men­tia is that these two con­di­tions have sim­i­lar risk fac­tors noted co-au­thor Dr Louis Ja­cob. “These fac­tors in­clude APOE4 al­lele of the apolipopro­tein E, a ma­jor choles­terol car­rier, lower vi­ta­min K lev­els, vi­ta­min D de­fi­ciency, but also an­dro­gens and oe­stro­gens.” The find­ings can be found pub­lished on­line in the Jour­nal of Alzheimer’s Dis­ease. – Re­laxnews

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