Do store in­sulin with a ther­mome­ter

The Borneo Post - Nature and health - - Front Page -

NEW RE­SEARCH has found that due to fluc­tu­a­tions in fridge tem­per­a­tures, di­a­betes pa­tients may be un­know­ingly stor­ing their med­i­ca­tion at the wrong tem­per­a­ture in their fridge, which could af­fect its po­tency. Car­ried out by DrKata­rina Braune from Char­ité - Univer­si­taetsmedi­zin Ber­lin in Ger­many in col­lab­o­ra­tion with Pro­fes­sor Lutz Heine­mann and the dig­i­tal health com­pany MedAn­gel BV, the new study set out to in­ves­ti­gate how of­ten in­sulin is stored by pa­tients at tem­per­a­tures that fall out­side the man­u­fac­turer’s rec­om­mended range.

The re­searchers re­cruited 388 di­a­betes pa­tients liv­ing in the USA and the EU and asked them to place MedAn­gel ONE tem­per­a­ture sen­sors ei­ther next to their in­sulin in the fridge and/or in their di­a­betes bag for in­sulin car­ried as a spare. The sen­sors au­to­mat­i­cally mea­sure the tem­per­a­ture ev­ery three min­utes, which is up to 480 times a day, be­fore send­ing the data to an app where it can be se­curely recorded. Tem­per­a­tures were recorded for an av­er­age of 49 days.

Af­ter analysing 400 tem­per­a­ture logs, in­clud­ing 230 for re­frig­er­ated in­sulin and 170 for car­ried in­sulin, the re­searchers found that 315 (79 per cent) were stored at tem­per­a­tures out­side of the rec­om­mended tem­per­a­ture range. On av­er­age, in­sulin stored in the fridge was out of the rec­om­mended tem­per­a­ture range 11 per­cent of the time, equiv­a­lent to two hours and 34 min­utes per day, although in­sulin car­ried in di­a­betes bags was only out- side tem­per­a­ture rec­om­men­da­tions for around eight min­utes a day.

Even more im­por­tantly, 66 sen­sors (17 per cent) mea­sured freez­ing tem­per­a­tures be­low 0ºC, equiv­a­lent to three hours a month on av­er­age. The find­ings, pre­sented at this year’s Euro­pean As­so­ci­a­tion for the Study of Di­a­betes (EASD) An­nual Meet­ing in Ber­lin, sug­gest that stor­ing in­sulin in do­mes­tic fridges may be im­pact­ing qual­ity. Many in­jectable drugs and vac­cines are highly sen­si­tive to heat and cold and can per­ish if their tem­per­a­ture changes even just a few de­grees.

In­sulin must stay be­tween 2-8°C/36-46°F in the re­frig­er­a­tor or 2-30°C/30-86°F when car­ried. “Many peo­ple with di­a­betes are un­wit­tingly stor­ing their in­sulin wrong be­cause of fluc­tu­at­ing tem­per­a­tures in do­mes­tic re­frig­er­a­tors,” says DrBraune. “When stor­ing your in­sulin in the fridge at home, al­ways use a ther­mome­ter to check the tem­per­a­ture. Long-term stor­age con­di­tions of in­sulin are known to have an im­pact on its blood-glu­cose low­er­ing ef­fect.

For peo­ple liv­ing with in­sulin-de­pen­dent di­a­betes who take in­sulin sev­eral times a day via in­jec­tions or con­tin­u­ously ad­min­is­ter in­sulin with a pump, pre­cise dos­ing is es­sen­tial to achieve op­ti­mal ther­a­peu­tic out­comes. Even grad­ual loss of po­tency in­tro­duces un­nec­es­sary vari­abil­ity in dos­ing. More re­search is needed to ex­am­ine the ex­tent to which tem­per­a­ture de­vi­a­tions dur­ing do­mes­tic stor­age af­fect in­sulin ef­fi­cacy and pa­tient out­comes.” – Re­laxnews

– iS­tock photo

Many di­a­betes pa­tients may be un­wit­tingly stor­ing their in­sulin at the wrong tem­per­a­ture, ac­cord­ing to new re­search.

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