An­tide­pres­sants cause lan­guage dis­or­ders in off­spring

The Sun (Malaysia) - - FAMILY TIES -

NEW US re­search has found a link be­tween tak­ing an­tide­pres­sants while preg­nant, and an in­creased risk of speech and/or lan­guage dis­or­ders in chil­dren.

The study, car­ried out by a team of re­searchers from Co­lum­bia Univer­sity’s Mail­man School of Pub­lic Health and the Co­lum­bia Univer­sity Med­i­cal Cen­tre, is be­lieved to be the first to look at a pos­si­ble as­so­ci­a­tion be­tween tak­ing SSRI (se­lec­tive sero­tonin re­up­take in­hibitors) an­tide­pres­sants while preg­nant and speech/lan­guage, scholas­tic, and mo­tor dis­or­ders in chil­dren.

SSRIs are be­ing in­creas­ingly used dur­ing preg­nancy, where they cross the pla­centa and en­ter the foetal cir­cu­la­tion.

To look at the ef­fect of their use the team used a large sam­ple of 845,345 sin­gle, live births be­tween 1996 and 2010 taken from na­tional reg­istries in Fin­land.

The chil­dren born fell into three dif­fer­ent groups: 15,596 were in the ex­posed group, whose moth­ers had pur­chased SSRIs once or more be­fore or dur­ing preg­nancy.

A to­tal of 9,537 chil­dren were the un­med­i­cated group, whose moth­ers had been di­ag­nosed with a psy­chi­atric disorder one year be­fore or dur­ing preg­nancy, but did not pur­chase SSRIs dur­ing preg­nancy; and 31,207 were in the un­ex­posed group, whose moth­ers had not been di­ag­nosed with a psy­chi­atric ill­ness and had no his­tory of pur­chas­ing SSRIs.

As ex­po­sure to SSRI was greater for moth­ers who made more than one SSRI pur­chase dur­ing the preg­nancy, the team also looked at how two or more pur­chases of SSRIs could also af­fect the risk of speech/ lan­guage dis­or­ders.

The re­sults showed that chil­dren of moth­ers who pur­chased SSRIs at least twice dur­ing preg­nancy had a 37% in­creased risk of speech and/or lan­guage dis­or­ders when com­pared to moth­ers who had de­pres­sion and other psy­chi­atric dis­or­ders, but who who were not treated with an­tide­pres­sants, al­though this group also showed an in­creased risk.

One of the study’s au­thors, Dr Alan Brown, noted that the study had many strengths, in­clud­ing its large sam­ple size, the prospec­tive data on SSRI pur­chases dur­ing preg­nancy, and a com­par­i­son group of moth­ers with de­pres­sion who were not tak­ing an­tide­pres­sants, but also added that the sever­ity of de­pres­sion could also be the rea­son for the as­so­ci­a­tion, and more re­search is needed. – AFPRe­laxnews

Newspapers in English

Newspapers from Malaysia

© PressReader. All rights reserved.