Treat­ment break­through?

Good Health Choices - - Be Informed -

A promis­ing study may have un­cov­ered a sim­ple way to im­prove

can­cer treat­ment. As a can­cer­ous tu­mour grows, large por­tions be­come de­prived of oxy­gen, mak­ing the con­di­tions inside those cells very

acidic. This acid­ity de­ac­ti­vates mTORC1, a molec­u­lar switch that’s re­spon­si­ble for giv­ing cells the goa­head to di­vide, which in turn puts

those parts of the tu­mour into a qui­es­cent state where pro­cesses are vir­tu­ally shut down, mak­ing them more re­sis­tant to im­munother­apy. But a study pub­lished in the jour­nal

Cell found that when mice were given bak­ing soda in their drink­ing water, it re­duced the acid­ity in the qui­es­cent

re­gions of tu­mours and ac­ti­vated mTORC1. Study lead au­thor Chi Van Dang, sci­en­tific di­rec­tor of the Lud­wig In­sti­tute for Can­cer Re­search, says that “by reawak­en­ing these cells, you could make the tu­mour far more sen­si­tive to ther­apy”.

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