BP pills be­fore sleep lower di­a­betes risk too

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Tak­ing blood pres­sure pills at bed­time rather than in the morn­ing re­duces BP dur­ing sleep and also low­ers risk of de­vel­op­ing Type 2 di­a­betes, re­search re­veals.

The team of Span­ish re­searchers found that there was a 57 per cent de­crease in the risk of de­vel­op­ing new-on­set Type 2 di­a­betes in the bed­time-treated group.

“In hy­per­ten­sive pa­tients with­out di­a­betes, in­ges­tion of the en­tire daily dose of one or more blood pres­sure-low­er­ing med­i­ca­tions at bed­time re­sults in sig­nif­i­cantly im­proved sleep­ing blood pres­sure con­trol and preven­tion of new-on­set di­a­betes,” said Ra­mon Her­mida from Univer­sity of Vigo, Spain.

The team did a ran­domised trial of 2,012 hy­per­ten­sive pa­tients with­out di­a­betes (976 men and 1,036 women)

Pa­tients were ran­domised to in­gest all their pre­scribed hy­per­ten­sion med­i­ca­tions upon awak­en­ing or the en­tire daily dose of one or more of them at bed­time.

In­ves­ti­ga­tors who did not know which pa­tients were in which group as­sessed the de­vel­op­ment of new-on­set di­a­betes.

Dur­ing a me­dian fol­low-up of six years, 171

par­tic­i­pants de­vel­oped Type 2 di­a­betes.

Pa­tients in the bed­time – com­pared with the morn­ingtreat­ment group – showed a sig­nif­i­cantly lower asleep mean BP and a greater sleep-time rel­a­tive BP de­cline.

In the bed­time-treated group, there was a low­er­preva­lence of a phe­nom­e­non known as “non-dip­ping” in which, pa­tients’ night time BP falls by less than 10 per­cent com­pared to day­time BP.

Fur­ther anal­y­sis showed that greater re­duc­tion in risk of de­vel­op­ing di­a­betes was ob­served for bed­time com­pared with awak­en­ing treat­ment.

The au­thors con­clude that reg­i­men of tak­ing an­ti­hy­per­ten­sive med­i­ca­tions be­fore bed is as safe as tak­ing them in the morn­ing.

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