Pan­cre­atic can­cer risk linked to changes in mouth bac­te­ria


THE pres­ence of cer­tain bac­te­ria in the mouth may in­di­cate a raised risk for pan cre­atic can­cer - a dis­ease that of­ten be­gins with no symp­toms and for which there is no rou­tine screen­ing test. This was the main con­clu­sion of a study led by NYU Lan­gone in New York, NY, pre­sented at the Amer­i­can As­so­ci­a­tion for Can­cer Re­search an­nual meet­ing in New Or­leans, LA, April 16-20, 2016.

The re­searchers sug­gest the find­ing may lead to ear­lier, more pre­cise treat­ments for pan­cre­atic can­cer, a dis­ease with a piti­fully low sur­vival rate as it of­ten es­capes early di­ag­no­sis. A his­tory of gum dis­ease and poor oral health have been linked to raised risk of pan­cre­atic can­cer, and some stud­ies have also sug­gested cer­tain types of mouth bac­te­ria may also play a role, but this is the first study to di­rectly eval­u­ate such a link, note the au­thors.

Se­nior au­thor Dr. Jiy­oung Ahn, epi­demi­ol­o­gist and as­so­ciate pro­fes­sor of pop­u­la­tion health and en­vi­ron­men­tal medicine at NYU School of Medicine, says: “Our study of­fers the first di­rect ev­i­dence that spe­cific changes in the mi­cro­bial mix in the mouth - the oral mi­cro­biome - rep­re­sent a likely risk fac­tor for pan­cre­atic can­cer along with older age, male gen­der, smok­ing, African-Amer­i­can race, and a fam­ily his­tory of the dis­ease.”

Es­ti­mates sug­gest over 46,000 Amer­i­cans were di­ag­nosed with pan­cre­atic can­cer and nearly 40,000 died of the dis­ease in 2014. For their study, the team com­pared the mouth bac- IS­LAM­ABAD—“De­vo­lu­tion of power to Lo­cal govern­ments is the ma­jor step to­wards good gov­er­nance and sus­tain­abil­ity of democ­racy”, says MNAAasiya Nasir. She was speak­ing to the par­tic­i­pants of a one day sem­i­nar here in Is­lam­abad, or­ga­nized by her es­teemed self and Kon­rad Ade­nauer Stiftung in Pakistan In­sti­tute for Par­lia­men­tary Ser­vices (PIPS) on the topic of “De­vo­lu­tion of Power to Lo­cal Govern­ments and Good Gov­er­nance”.

She also said that with­out de­vo­lu­tion of power, as­pect of good gov­er­nance can­not be achieved. And not only de­vo­lu­tion but Em­pow­ered de­vo­lu­tion is re­quired to strengthen the lo­cal govern­ment sys­tem.

Syed Zee­shan Naqvi, Deputy Mayor Is­lam­abad stated that Is­lam­abad Metropoli­tan Cor­po­ra­tion is ready to take action for the ex­ist­ing is­sues of Is­lam­abad es­pe­cially re­lated to wa­ter, san­i­ta­tion, health and education. He ap­pre­ci­ated the ef­forts done by Prime Min­is­ter Nawaz Sharif for con­duct­ing Lo­cal Govern­ment Elec­tions in Is­lam­abad and as­sured that Metropoli­tan Cor­po­ra­tion of Is­lam­abad will ful­fill the ex­pec­ta­tions of its masses.

Mr. Ronny Heine, Res­i­dent Rep­re­sen­ta­tive of Kon­rad Ade­nauer Stiftung ac­knowl­edged and ap­pre­ci­ated the co­op­er­a­tion and com­mit­ment shown by Mem­bers of Na­tional Assembly by teria sam­pled from 361 Amer­i­can men and women be­fore they de­vel­oped pan­cre­atic can­cer with those sam­pled from 371 sim­i­lar in­di­vid­u­als who did not de­velop the dis­ease. The par­tic­i­pants were tak­ing part in larger, ongoing stud­ies of can­cer risk, where they had been given mouth­wash sam­ples when they joined the stud­ies. They were fol­lowed for nearly 10 years, dur­ing which any can­cer di­ag­noses were noted.

When they an­a­lyzed the re­sults, Prof. Ahn and col­leagues found that par­tic­i­pants whose mouth bac­te­ria con­tained ei­ther of two cer­tain types had a higher risk of de­vel­op­ing pan­cre­atic can­cer, com­pared with par­tic­i­pants whose oral mi­cro­biome showed no ev­i­dence of the micro­organ­isms. Specif­i­cally, they found pres­ence of Por­phy­romonas gin­gi­valis was linked to a 59% over­all higher risk of de­vel­op­ing pan­cre­atic can­cer. Sim­i­larly, pres­ence of Ag­gre­gat­i­bac­ter acti­no­mycetem­comi­tans was linked to a 50% over­all higher risk. Both types of bac­te­ria are known to be as­so­ci­ated with gum dis­ease or pe­ri­odon­ti­tis.

The fig­ures did not change when the re­searchers took out cases where par­tic­i­pants were di­ag­nosed with pan­cre­atic can­cer in the 2 years fol­low­ing col­lec­tion of the sam­ples. They did this to re­duce the chance that the fig­ures were in­flu­enced by “re­verse cau­sa­tion,” that is, the pres­ence of the can­cer pre­ced­ing the pres­ence of the two bac­te­ria. In an­other study pub­lished re­cently, the team shows that smok­ing is tied to dra­matic - but not ir­re­versible - changes in mouth bac­te­ria, both in amounts and mix. join­ing the Sem­i­nar. He ex­pected that to­day’s Sem­i­nar will not only help in high­light­ing the ex­ist­ing is­sues at lo­cal level but will also high­light the pos­si­bil­i­ties to strengthen and em­power the lo­cal govern­ment sys­tem. While in­tro­duc­ing Kon­rad Ade­nauer Stiftung he in­formed the au­di­ence that this Ger­man Po­lit­i­cal Foun­da­tion aims to strengthen democ­racy, rule of law and gov­er­nance in Pakistan.

Dr. Amna Mehmood, Ex­pert in Po­lit­i­cal Science and IR, Is­lamic In­ter­na­tional Univer­sity stated that In­tra-Party democ­racy is the first step to­wards trans­parency which will ul­ti­mately strengthen our na­tional democ­racy. She high­lighted the chal­lenges faced by lo­cal govern­ment in­clud­ing ex­ces­sive de­mands from vot­ers, un­e­d­u­cated masses, lack of po­lit­i­cal so­cial­iza­tion and mo­bi­liza­tion, re­sis­tance from bu­reau­cracy, is­suance of bud­get and funds as well as a bet­ter im­ple­men­ta­tion of the sys­tem.

Mr. Fau­mir As­ghar, Dis­trict Chair­man Narowal, ex­pressed that democ­racy should evolve from the grass roots level. Provin­cial and Na­tional As­sem­blies can­not ad­dress the is­sues at lo­cal level. He was of the view that fu­ture of lo­cal democ­racy lies with fu­ture of lo­cal govern­ments. Dr. Fouzia Hameed, MNA (MQM), also en­light­ened the au­di­ence by ex­press­ing her views on Gen­der Main­stream­ing and Sig­nif­i­cance of Women Par­tic­i­pa­tion in Lo­cal Govern­ments. IS­LAM­ABAD—Ad­vi­sor to Prime Min­is­ter on Na­tional His­tory and Lit­er­ary Her­itage Ir­fan Sid­diqui on Tues­day directed Depart­ment of Arche­ol­ogy and Mu­seum (DAM) to plan con­struc­tion of Na­tional Mu­seum in fed­eral cap­i­tal on im­me­di­ate ba­sis.

He stated this in a meet­ing held here at Na­tional His­tory and Lit­er­ary Her­itage di­vi­sion, said a press re­lease.

In the meet­ing, Na­tional Lan­guage Pro­mo­tion Depart­ment (NLPD) and DAM briefed the Ad­vi­sor to PM on per­for­mance and fu­ture plans of the de­part­ments. Sec­re­tary NH&LH Di­vi­sion Mohsin S. Haqqani, DG NLPD Saqib Aleem, Joint Sec­re­tary Mash­hood Mirza and other se­nior of­fi­cials of NH&LH Di­vi­sion also at­tended the meet­ing.

On the di­rec­tives of Ad­vi­sor to PM, a spe­cial committee was con­sti­tuted for the trans­la­tion of stan­dard Urdu.

The Ad­vi­sor to PM also directed the of­fi­cials to achieve the set tar­get of im­ple­ment­ing Na­tional lan­guage within time as per di­rec­tives of Supreme Court or­der and Constitutional obli­ga­tion.

On the oc­ca­sion, NLPD and DAM se­nior of­fi­cials briefed the Ad­vi­sor to PM about the per­for­mance and fu­ture tar­gets of the de­part­ments.

It was in­formed that for the im­ple­men­ta­tion of Na­tional lan­guage a spe­cial book­let was com­piled while Sec­re­tariat Train­ing In­sti­tute is pro­vid­ing train­ing for the pur­pose.

It was stated that ef­forts are be­ing in progress for the com­put­er­i­za­tion of Urdu data with var­i­ous as­pects, adding that Min­istry of In­for­ma­tion Tech­nol­ogy would be re­quested for as­sis­tance in de­vel­op­ing E-fil­ing sys­tem.

The Ad­vi­sor to Prime Min­is­ter also said that with na­tional spirit Urdu can be im­ple­mented as of­fice lan­guage, adding that mod­ern tech­nol­ogy should be fo­cused for as­sis­tance in this re­gard.

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