Pancreatic cancer risk linked to changes in mouth bacteria
THE presence of certain bacteria in the mouth may indicate a raised risk for pan creatic cancer - a disease that often begins with no symptoms and for which there is no routine screening test. This was the main conclusion of a study led by NYU Langone in New York, NY, presented at the American Association for Cancer Research annual meeting in New Orleans, LA, April 16-20, 2016.
The researchers suggest the finding may lead to earlier, more precise treatments for pancreatic cancer, a disease with a pitifully low survival rate as it often escapes early diagnosis. A history of gum disease and poor oral health have been linked to raised risk of pancreatic cancer, and some studies have also suggested certain types of mouth bacteria may also play a role, but this is the first study to directly evaluate such a link, note the authors.
Senior author Dr. Jiyoung Ahn, epidemiologist and associate professor of population health and environmental medicine at NYU School of Medicine, says: “Our study offers the first direct evidence that specific changes in the microbial mix in the mouth - the oral microbiome - represent a likely risk factor for pancreatic cancer along with older age, male gender, smoking, African-American race, and a family history of the disease.”
Estimates suggest over 46,000 Americans were diagnosed with pancreatic cancer and nearly 40,000 died of the disease in 2014. For their study, the team compared the mouth bac- ISLAMABAD—“Devolution of power to Local governments is the major step towards good governance and sustainability of democracy”, says MNAAasiya Nasir. She was speaking to the participants of a one day seminar here in Islamabad, organized by her esteemed self and Konrad Adenauer Stiftung in Pakistan Institute for Parliamentary Services (PIPS) on the topic of “Devolution of Power to Local Governments and Good Governance”.
She also said that without devolution of power, aspect of good governance cannot be achieved. And not only devolution but Empowered devolution is required to strengthen the local government system.
Syed Zeeshan Naqvi, Deputy Mayor Islamabad stated that Islamabad Metropolitan Corporation is ready to take action for the existing issues of Islamabad especially related to water, sanitation, health and education. He appreciated the efforts done by Prime Minister Nawaz Sharif for conducting Local Government Elections in Islamabad and assured that Metropolitan Corporation of Islamabad will fulfill the expectations of its masses.
Mr. Ronny Heine, Resident Representative of Konrad Adenauer Stiftung acknowledged and appreciated the cooperation and commitment shown by Members of National Assembly by teria sampled from 361 American men and women before they developed pancreatic cancer with those sampled from 371 similar individuals who did not develop the disease. The participants were taking part in larger, ongoing studies of cancer risk, where they had been given mouthwash samples when they joined the studies. They were followed for nearly 10 years, during which any cancer diagnoses were noted.
When they analyzed the results, Prof. Ahn and colleagues found that participants whose mouth bacteria contained either of two certain types had a higher risk of developing pancreatic cancer, compared with participants whose oral microbiome showed no evidence of the microorganisms. Specifically, they found presence of Porphyromonas gingivalis was linked to a 59% overall higher risk of developing pancreatic cancer. Similarly, presence of Aggregatibacter actinomycetemcomitans was linked to a 50% overall higher risk. Both types of bacteria are known to be associated with gum disease or periodontitis.
The figures did not change when the researchers took out cases where participants were diagnosed with pancreatic cancer in the 2 years following collection of the samples. They did this to reduce the chance that the figures were influenced by “reverse causation,” that is, the presence of the cancer preceding the presence of the two bacteria. In another study published recently, the team shows that smoking is tied to dramatic - but not irreversible - changes in mouth bacteria, both in amounts and mix. joining the Seminar. He expected that today’s Seminar will not only help in highlighting the existing issues at local level but will also highlight the possibilities to strengthen and empower the local government system. While introducing Konrad Adenauer Stiftung he informed the audience that this German Political Foundation aims to strengthen democracy, rule of law and governance in Pakistan.
Dr. Amna Mehmood, Expert in Political Science and IR, Islamic International University stated that Intra-Party democracy is the first step towards transparency which will ultimately strengthen our national democracy. She highlighted the challenges faced by local government including excessive demands from voters, uneducated masses, lack of political socialization and mobilization, resistance from bureaucracy, issuance of budget and funds as well as a better implementation of the system.
Mr. Faumir Asghar, District Chairman Narowal, expressed that democracy should evolve from the grass roots level. Provincial and National Assemblies cannot address the issues at local level. He was of the view that future of local democracy lies with future of local governments. Dr. Fouzia Hameed, MNA (MQM), also enlightened the audience by expressing her views on Gender Mainstreaming and Significance of Women Participation in Local Governments. ISLAMABAD—Advisor to Prime Minister on National History and Literary Heritage Irfan Siddiqui on Tuesday directed Department of Archeology and Museum (DAM) to plan construction of National Museum in federal capital on immediate basis.
He stated this in a meeting held here at National History and Literary Heritage division, said a press release.
In the meeting, National Language Promotion Department (NLPD) and DAM briefed the Advisor to PM on performance and future plans of the departments. Secretary NH&LH Division Mohsin S. Haqqani, DG NLPD Saqib Aleem, Joint Secretary Mashhood Mirza and other senior officials of NH&LH Division also attended the meeting.
On the directives of Advisor to PM, a special committee was constituted for the translation of standard Urdu.
The Advisor to PM also directed the officials to achieve the set target of implementing National language within time as per directives of Supreme Court order and Constitutional obligation.
On the occasion, NLPD and DAM senior officials briefed the Advisor to PM about the performance and future targets of the departments.
It was informed that for the implementation of National language a special booklet was compiled while Secretariat Training Institute is providing training for the purpose.
It was stated that efforts are being in progress for the computerization of Urdu data with various aspects, adding that Ministry of Information Technology would be requested for assistance in developing E-filing system.
The Advisor to Prime Minister also said that with national spirit Urdu can be implemented as office language, adding that modern technology should be focused for assistance in this regard.