Sleep de­pri­va­tion may lower ‘ good’ choles­terol

Pakistan Observer - - KARACHI CITY -

PRE­VI­OUS stud­ies have sug­gested that lack of sleep may in­crease the risk for car­dio­vas­cu­lar disease, and a new study may help ex­plain why; re­searchers found that sleep de­pri­va­tion may have a neg­a­tive im­pact on choles­terol lev­els. Pub­lished in the jour­nal Sci­en­tific Re­ports, the study found that sleep loss leads to changes in genes that are re­spon­si­ble for reg­u­lat­ing choles­terol lev­els.

What is more, two pop­u­la­tion co­horts re­veal that peo­ple who ex­pe­ri­ence sleep de­pri­va­tion may have fewer high- den­sity lipopro­teins ( HDL) - known as the “good” choles­terol - than those who have suf­fi­cient sleep. HDL choles­terol is re­spon­si­ble for re­mov­ing low­den­sity lipopro­teins ( LDL) - the “bad” choles­terol - from the ar­ter­ies. LDL choles­terol con­trib­utes to ath­er­o­scle­ro­sis - a build- up of plaque in the ar­ter­ies that can in­crease the risk for heart at­tack and stroke - so a ro­bust HDL choles­terol level is im­por­tant for pro­tect­ing heart health.

The team reached its find­ings by con­duct­ing ex­per­i­men­tal and epi­demi­o­log­i­cal analy­ses. For the ex­per­i­men­tal anal­y­sis, the re­searchers en­rolled 21 par­tic­i­pants who were re­quired to sleep in a lab­o­ra­tory- con­trolled con­di­tion for 5 nights The sleep du­ra­tion for 14 of th­ese par­tic­i­pants was re­stricted to just 4 hours a night, while the re­main­ing seven par­tic­i­pants en­joyed suf­fi­cient sleep each night.

Blood sam­ples were taken from all sub­jects dur­ing the study pe­riod, which the team an­a­lyzed for gene ex­pres­sion and lipopro­tein lev­els. Com­pared with par­tic­i­pants who had suf­fi­cient sleep, the re­searchers found that those who ex­pe­ri­enced sleep loss had re­duced ex­pres­sion for genes that en­code for lipopro­teins - that is, there was re­duced ac­tiv­ity in genes that are re­spon­si­ble for reg­u­lat­ing choles­terol lev­els. For the epi­demi­o­log­i­cal anal­y­sis, the re­searchers as­sessed the data of 2,739 par­tic­i­pants from one of two Fin­nish pop­u­la­tion stud­ies: Di­etary, Life­style and Ge­netic de­ter­mi­nants of Obe­sity and Meta­bolic syn­drome ( DIL­GOM) study, and the Car­dio­vas­cu­lar Risk in Young Finns Study ( YFS).

In the DIL­GOM study, par­tic­i­pants com­pleted ques­tion­naires in which they were asked whether they got enough sleep each night. Sub­jects who an­swered “sel­dom” or “never” were deemed as hav­ing “sub­jec­tive sleep in­suf­fi­ciency.” In the YFS study, sub­jects were asked how many hours they slept each night and how many hours they need each night to fell well- rested. Their sub­jec­tive sleep du­ra­tion was then sub­tracted from their sub­jec­tive sleep need in or­der to de­ter­mine which par­tic­i­pants could be deemed as hav­ing sleep de­pri­va­tion.

On an­a­lyz­ing the blood sam­ples of the par­tic­i­pants, once again, the re­searchers found that sub­jects who were not get­ting suf­fi­cient sleep had re­duced ex­pres­sion of lipopro­teinen­cod­ing genes, com­pared with those who were get­ting enough sleep. Ad­di­tion­ally, sub­jects who were ex­pe­ri­enc­ing lack of sleep had lower lev­els of cir­cu­lat­ing HDL.

Newspapers in English

Newspapers from Pakistan

© PressReader. All rights reserved.