Fruit com­pounds could help treat obe­sity, type 2 di­a­betes, and CVD

Pakistan Observer - - TWIN CITIES -

ADAILY sup­ple­ment con­sist­ing of com­pounds de­rived from red grapes and or­anges could of­fer a promis­ing new treat­ment for obe­sity, type 2 di­a­betes, and car­dio­vas­cu­lar dis­ease. This is the con­clu­sion of a new study by re­searchers from the Uni­ver­sity of War­wick in the United King­dom. In the jour­nal Di­a­betes, re­searchers re­veal that the two fruit com­pounds work to­gether to re­duce blood glu­cose lev­els, im­prove in­sulin ac­tiv­ity, and boost the health of ar­ter­ies.

Obe­sity af­fects more than a third of adults in the United States, rais­ing their risk of heart dis­ease, type 2 di­a­betes, stroke, and some forms of cancer. At the same time, car­dio­vas­cu­lar dis­ease (CVD) - a term used to de­scribe dis­eases of the heart and blood ves­sels - is re­spon­si­ble for around 1 in 3 deaths in the U.S., while di­a­betes af­fects around 9.3 per­cent of Amer­i­cans. Such sta­tis­tics high­light the need for more ef­fec­tive treat­ment strate­gies for th­ese con­di­tions.

Now, study leader Paul Thor­nal­ley, pro­fes­sor in sys­tems bi­ol­ogy at War­wick, and col­leagues sug­gest red grapes and or­anges may pave the way for such treat­ments. For their study, the team in­ves­ti­gated the ef­fects of a com­pound called trans-resver­a­trol (tRES), found in red grapes, and a com­pound found in or­anges called hes­peretin (HESP). On test­ing a com­bi­na­tion of the com­pounds in cell cul­ture, the re­searchers found that it in­creased ex­pres­sion of gly­ox­alase 1 (Glo1) an enzyme that neu­tral­izes a com­pound called methyl­gly­oxal (MG).

The team ex­plains that MG is a key driver of sugar’s harm­ful ef­fects on the body; a com­bi­na­tion of high MG lev­els and a high-calo­rie diet is a cause of in­sulin re­sis­tance, which can lead to type 2 di­a­betes. It also dam­ages blood ves­sels and can drive high choles­terol lev­els - a risk fac­tor for CVD. As such, the team hy­poth­e­sizes that block­ing MG by in­creas­ing Glo1 ex­pres­sion could re­verse th­ese ef­fects.

“Obe­sity, type 2 di­a­betes and car­dio­vas­cu­lar dis­ease are at epi­demic lev­els in West­ern­ised coun­tries. Glo1 de­fi­ciency has been iden­ti­fied as a driver of health prob­lems in obe­sity, di­a­betes and car­dio­vas­cu­lar dis­ease,” notes Prof. Thor­nal­ley. Next, the team tested the tRES-HESP com­bi­na­tion on 32 adults aged 18-80 who had a body mass in­dex (BMI) of between 25-40, fall­ing into the over­weight or obese cat­e­gories.

Par­tic­i­pants were given the fruit com­pound com­bi­na­tion in the form of a sup­ple­ment, which they were asked to take once a day for 8 weeks. Dur­ing the study pe­riod, sub­jects were asked to con­tinue with their usual di­ets and not to in­crease phys­i­cal ac­tiv­ity, en­abling the re­searchers to gain a more ac­cu­rate pic­ture of the sup­ple­ments’ ef­fects.

Newspapers in English

Newspapers from Pakistan

© PressReader. All rights reserved.