Fruit compounds could help treat obesity, type 2 diabetes, and CVD
ADAILY supplement consisting of com pounds derived from red grapes and or anges could offer a promising new treatment for obesity, type 2 diabetes, and cardiovascular disease. This is the conclusion of a new study by researchers from the University of Warwick in the United Kingdom. In the journal Diabetes, researchers reveal that the two fruit compounds work together to reduce blood glucose levels, improve insulin activity, and boost the health of arteries.
Obesity affects more than a third of adults in the United States, raising their risk of heart disease, type 2 diabetes, stroke, and some forms of cancer. At the same time, cardiovascular disease (CVD) - a term used to describe diseases of the heart and blood vessels - is responsible for around 1 in 3 deaths in the U.S., while diabetes affects around 9.3 percent of Americans. Such statistics highlight the need for more effective treatment strategies for these conditions.
Now, study leader Paul Thornalley, professor in systems biology at Warwick, and colleagues suggest red grapes and oranges may pave the way for such treatments. For their study, the team investigated the effects of a compound called trans-resveratrol (tRES), found in red grapes, and a compound found in oranges called hesperetin (HESP). On testing a combination of the compounds in cell culture, the researchers found that it increased expression of glyoxalase 1 (Glo1) - an enzyme that neutralizes a methylglyoxal (MG).
The team explains that MG is a key driver of sugar’s harmful effects on the body; a combination of high MG levels and a high-calorie diet is a cause of insulin resistance, which can lead to type 2 diabetes. It also damages blood vessels and can drive high cholesterol levels - a risk factor for CVD. As such, the team hypothesizes that blocking MG by increasing Glo1 expression could reverse these effects.
“Obesity, type 2 diabetes and cardiovascular disease are at epidemic levels in Westernised countries. Glo1 deficiency has been identified as a driver of health problems in obesity, diabetes and cardiovascular disease,” notes Prof. Thornalley. Next, the team tested the tRES-HESP combination on 32 adults aged 18-80 who had a body mass index (BMI) of between 25-40, falling into the overweight or obese categories.
Participants were given the fruit compound combination in the form of a supplement, which they were asked to take once a day for 8 weeks. During the study period, subjects were asked to continue with their usual diets and not to increase physical activity, enabling the researchers to gain a more accurate picture of the supplements’ effects. Blood samples were taken from participants on a regular basis during the 8-week period and analysed for sugar levels and other blood markers. The artery health of the participants was assessed by measuring artery wall flexibility. compound called LAHORE—Protest by teachers of different government schools in Punjab continued for the second day on Sunday here against what they called privatisation of public schools.
A large number of teachers from different parts of the province on Saturday had gathered for a sit-in in front of the Punjab Assembly, protesters spent the night outside the assembly building and refused to end the sit-in until their demands were met.
Punjab Teachers Union (PTU) had given the call for the demonstra- tion in which, despite hot weather, male and female teachers from the neighboring districts also participated and expressed strong resentment over the policies of the Education Department.
The teachers raised their voice against a recent policy of the education department under which public sector primary schools are proposed to be handed over to the private sector on the “pretext of poor performance”.
The PTU leaders recently had claimed that some schools were being ‘privatised’ despite good performance, terming the move a conspiracy to jeopardise the entire system of public education in the province.
The protesting teachers chanted slogans and vowed to continue their protest till the acceptance of their demands, including upgradation of teachers.
PTU President Sajjad Akbar Kazmi who led the demonstration said Punjab Chief Minister Shahbaz Sharif instead of listening to bureaucracy should listen to the real stakeholders, the teachers. He said the gathering of hundreds of teachers was proof of the fact that there was great unrest among schoolteachers owing to the education department’s policies.
Sajjad Kazmi, Rana Liaqat, Jam Sadiq, Ch Sarfraz, Rana Anwaar and other leaders said the good performing schools were also being handed over to Punjab Daanish Schools and Centers of Excellence Authority to turn the same as ‘centers of excellence’ despite the fact these schools were already performing well.
Leaders of the Punjab Teachers Union demanded that the government not ‘outsource’ the public schools after which they would be sacked and their replacements hired at minimum monthly honorariums. (ENDS).