Fruit com­pounds could help treat obe­sity, type 2 di­a­betes, and CVD

Pakistan Observer - - LAHORE CITY - STAFF RE­PORTER

ADAILY sup­ple­ment con­sist­ing of com pounds de­rived from red grapes and or anges could of­fer a promis­ing new treat­ment for obe­sity, type 2 di­a­betes, and car­dio­vas­cu­lar dis­ease. This is the con­clu­sion of a new study by re­searchers from the Uni­ver­sity of War­wick in the United King­dom. In the jour­nal Di­a­betes, re­searchers re­veal that the two fruit com­pounds work to­gether to re­duce blood glu­cose lev­els, im­prove in­sulin ac­tiv­ity, and boost the health of ar­ter­ies.

Obe­sity af­fects more than a third of adults in the United States, rais­ing their risk of heart dis­ease, type 2 di­a­betes, stroke, and some forms of cancer. At the same time, car­dio­vas­cu­lar dis­ease (CVD) - a term used to de­scribe dis­eases of the heart and blood ves­sels - is re­spon­si­ble for around 1 in 3 deaths in the U.S., while di­a­betes af­fects around 9.3 per­cent of Amer­i­cans. Such sta­tis­tics high­light the need for more ef­fec­tive treat­ment strate­gies for th­ese con­di­tions.

Now, study leader Paul Thor­nal­ley, pro­fes­sor in sys­tems bi­ol­ogy at War­wick, and col­leagues sug­gest red grapes and or­anges may pave the way for such treat­ments. For their study, the team in­ves­ti­gated the ef­fects of a com­pound called trans-resver­a­trol (tRES), found in red grapes, and a com­pound found in or­anges called hes­peretin (HESP). On test­ing a com­bi­na­tion of the com­pounds in cell cul­ture, the re­searchers found that it in­creased ex­pres­sion of gly­ox­alase 1 (Glo1) - an enzyme that neu­tral­izes a methyl­gly­oxal (MG).

The team ex­plains that MG is a key driver of sugar’s harm­ful ef­fects on the body; a com­bi­na­tion of high MG lev­els and a high-calo­rie diet is a cause of in­sulin re­sis­tance, which can lead to type 2 di­a­betes. It also dam­ages blood ves­sels and can drive high choles­terol lev­els - a risk fac­tor for CVD. As such, the team hy­poth­e­sizes that block­ing MG by in­creas­ing Glo1 ex­pres­sion could re­verse th­ese ef­fects.

“Obe­sity, type 2 di­a­betes and car­dio­vas­cu­lar dis­ease are at epi­demic lev­els in West­ern­ised coun­tries. Glo1 de­fi­ciency has been iden­ti­fied as a driver of health prob­lems in obe­sity, di­a­betes and car­dio­vas­cu­lar dis­ease,” notes Prof. Thor­nal­ley. Next, the team tested the tRES-HESP com­bi­na­tion on 32 adults aged 18-80 who had a body mass in­dex (BMI) of between 25-40, fall­ing into the over­weight or obese cat­e­gories.

Par­tic­i­pants were given the fruit com­pound com­bi­na­tion in the form of a sup­ple­ment, which they were asked to take once a day for 8 weeks. Dur­ing the study pe­riod, sub­jects were asked to con­tinue with their usual di­ets and not to in­crease phys­i­cal ac­tiv­ity, en­abling the re­searchers to gain a more ac­cu­rate pic­ture of the sup­ple­ments’ ef­fects. Blood sam­ples were taken from par­tic­i­pants on a reg­u­lar ba­sis dur­ing the 8-week pe­riod and an­a­lysed for sugar lev­els and other blood mark­ers. The artery health of the par­tic­i­pants was as­sessed by mea­sur­ing artery wall flex­i­bil­ity. com­pound called LA­HORE—Protest by teach­ers of dif­fer­ent gov­ern­ment schools in Pun­jab con­tin­ued for the sec­ond day on Sun­day here against what they called pri­vati­sa­tion of pub­lic schools.

A large num­ber of teach­ers from dif­fer­ent parts of the province on Satur­day had gath­ered for a sit-in in front of the Pun­jab As­sem­bly, pro­test­ers spent the night out­side the as­sem­bly build­ing and re­fused to end the sit-in un­til their de­mands were met.

Pun­jab Teach­ers Union (PTU) had given the call for the demon­stra- tion in which, de­spite hot weather, male and fe­male teach­ers from the neigh­bor­ing dis­tricts also par­tic­i­pated and ex­pressed strong re­sent­ment over the poli­cies of the Ed­u­ca­tion De­part­ment.

The teach­ers raised their voice against a re­cent pol­icy of the ed­u­ca­tion de­part­ment un­der which pub­lic sec­tor pri­mary schools are pro­posed to be handed over to the pri­vate sec­tor on the “pre­text of poor per­for­mance”.

The PTU lead­ers re­cently had claimed that some schools were be­ing ‘pri­va­tised’ de­spite good per­for­mance, terming the move a con­spir­acy to jeop­ar­dise the en­tire sys­tem of pub­lic ed­u­ca­tion in the province.

The protest­ing teach­ers chanted slo­gans and vowed to con­tinue their protest till the ac­cep­tance of their de­mands, in­clud­ing upgra­da­tion of teach­ers.

PTU Pres­i­dent Sa­j­jad Ak­bar Kazmi who led the demon­stra­tion said Pun­jab Chief Min­is­ter Shah­baz Sharif in­stead of lis­ten­ing to bu­reau­cracy should lis­ten to the real stake­hold­ers, the teach­ers. He said the gath­er­ing of hun­dreds of teach­ers was proof of the fact that there was great un­rest among schoolteach­ers ow­ing to the ed­u­ca­tion de­part­ment’s poli­cies.

Sa­j­jad Kazmi, Rana Li­aqat, Jam Sadiq, Ch Sar­fraz, Rana An­waar and other lead­ers said the good per­form­ing schools were also be­ing handed over to Pun­jab Daan­ish Schools and Cen­ters of Ex­cel­lence Au­thor­ity to turn the same as ‘cen­ters of ex­cel­lence’ de­spite the fact th­ese schools were al­ready per­form­ing well.

Lead­ers of the Pun­jab Teach­ers Union de­manded that the gov­ern­ment not ‘out­source’ the pub­lic schools af­ter which they would be sacked and their re­place­ments hired at min­i­mum monthly hon­o­rar­i­ums. (ENDS).

Newspapers in English

Newspapers from Pakistan

© PressReader. All rights reserved.