CHANTE

The Philippine Star - - NEWS OPINION -

pa­tients, only 14 had elec­tro­phys­i­o­logic data con­sis­tent with the Guil­lain-Barre syn­drome and there­fore could have met Brighton level 1 di­ag­nos­tic cri­te­ria for the syn­drome. Among the 25 ZIKV poly­merase chain re­ac­tions – neg­a­tive pa­tients, dengue virus (DENV) lgG an­ti­bod­ies were present in the cere­brospinal fluid of 12 pa­tients and in the serum of 10 pa­tients, and serum DENV lgM test re­sults were pos­i­tive in 1. These data raise the pos­si­bil­ity of pri­mary DENV in­fec­tion and false-pos­i­tive ZIKV sero­logic test re­sults from cross­re­ac­tiv­ity.

Over­all, the study sup­ports the as­so­ci­a­tion between ZIKV and the Guil­lain-Barre syn­drome, although con­fir­ma­tion in another co­hort would strengthen this as­ser­tion. Although high rates of seropos­i­tiv­ity may prove pro­tec­tive against fur­ther waves of ZIKV-re­lated Guil­lain-Barre syn­drome in Cen­tral and South Amer­ica,the ZIKV pan­demic is just be­gin­ning in North Amer­ica and Africa, and an in­crease in the in­ci­dence of the Guil­lan-Barre syn­drome may fol­low.

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