HBKU DE­VEL­OPS AL­GO­RITHM FOR BRAIN CANCER MARK­ERS

Qatar Today - - CITY > DOHA DIARY -

Sci­en­tists from the Qatar Com­put­ing Re­search In­sti­tute (QCRI), part of Ha­mad Bin Khalifa Univer­sity (HBKU), have de­vel­oped a new al­go­rithm that can iden­tify driver genes of sev­eral types of gliomas, the most com­mon and ag­gres­sive forms of pri­mary brain tu­mours.

The QCRI sci­en­tists, in­clud­ing Dr Raghvendra Mall, Dr Hal­ima Bens­mail and Khalid Kunji, built a ma­chine-learn­ing al­go­rithm that can iden­tify the main reg­u­la­tors of sep­a­rate brain tu­mours.

“The al­go­rithm out­per­forms state-of-theart meth­ods for genome-wide gene regulatory net­work in­fer­ence by in­cor­po­rat­ing prior bi­o­log­i­cal knowl­edge and regularisation to prune false pos­i­tives,” said Dr Mall.

Knowl­edge of the pur­pose of these driver genes and the sta­tus of these cancer sub­types could fur­ther as­sist in the search for treat­ments or prog­nos­tic in­for­ma­tion in both glioma and other cancer types. The work re­veals the iden­tity and bi­o­log­i­cal ac­tiv­i­ties of the main genes that reg­u­late and char­ac­terise the dif­fer­ences be­tween dif­fer­ent glioma sub­types.

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