Major breakthrough in the quest for an Ebola vaccine
An Ebola test vaccine provided blanket protection in a field trial in Guinea, researchers said Friday, possibly heralding “the beginning of the end” for the devastating West African outbreak that has killed thousands.
The serum was 100 percent effective after a week in more than 7,600 people inoculated, according to results published in The Lancet medical journal and hailed as “extremely promising” by World Health Organization (WHO) chief Margaret Chan.
The world was “on the verge of an effective Ebola vaccine,” the U.N.’s health agency said in a statement.
“The initial results of the study show that the vaccine can effectively contain the further spread of the Ebola virus,” said the University of Bern, which contributed to the research.
Though encouraging, the results are “interim” and the vaccine will not become immediately available as a community-wide Ebola shield, experts cautioned.
About 28,000 people have been infected in Guinea, Sierra Leone and Liberia since late 2013, according to the WHO. Nearly half have died, but there is thought to be a large undercount of cases and deaths.
Having brought an already fragile health sector to its knees, and driving out much-needed investment, the outbreak has started winding down but is not over.
Seven cases were confirmed the week ending in July 26 — four in Guinea and three in Sierra Leone — the lowest weekly total for over a year.
But even a single undetected case can spark a flareup — the virus spreads through direct contact with body fluids.
More Tests Required
One of two leading vaccine candidates, VSV-ZEBOV has been developed and tested in a superquick 12 months, compared to the normal decade or more. Ebola has no licensed cure or treatment.
The trial, backed by drug firm Merck, the WHO and the governments of Canada, Norway and Guinea, saw 4,123 high-risk people vaccinated immediately after someone close to the trial participant fell ill with the hemorrhagic fever.
None of the vaccinated group caught the virus.
A second, comparison group of 3,528 people received the vaccine three weeks after potential exposure. Sixteen of them contracted the virus while unprotected, said the study, but by day six after inoculation, everyone in the second group was also fully shielded.
“Indeed, no vaccine developed symptoms more than six days after vaccination, irrespective of whether vaccination was immediate or delayed,” said the study paper.
The vaccine was safe, with no serious side-effects, according to the study. Not known is how long the protection lasts, or the vaccine’s effect on pregnant women and children — high risk groups not included in the trial.
The WHO’s representative in Guinea, Mohammed Belhocine, advised caution, however. “Given the danger of this epidemic, this is just a partial result. We should celebrate it, but must not allow our guard to drop,” he said.