NTU re­searchers iden­tify lung can­cer-re­lated mu­ta­tion

The China Post - - LOCAL -

A re­search team from Na­tional Tai­wan Univer­sity (NTU) has suc­ceeded in iden­ti­fy­ing a genome mu­ta­tion highly cor­re­lated with lung can­cer us­ing rapid whole-genome se­quenc­ing tech­nol­ogy, and the dis­cov­ery can im­prove the di­ag­no­sis of early stage lung can­cer.

At a press brief­ing Thurs­day, re­searchers said that lung can­cer re­mained the No. 1 killer among all dis­eases in Tai­wan. Most lung can­cers are first di­ag­nosed based on symp­toms, but symp­toms of early-stage lung can­cer are not very spe­cific, thus caus­ing dif­fi­cul­ties in screen­ing.

At the mo­ment, the only method to iden­tify groups with a high risk of de­vel­op­ing lung can­cer is re­sort­ing to fa­mil­ial pen­e­trance.

In or­der to iden­tify the risk fac­tors, the re­search team con­ducted a study of a fam­ily with an atyp­i­cally high den­sity of lung can­cer. By an­a­lyz­ing the data col­lected in the process of con­duct­ing rapid wholegenome se­quenc­ing of fam­ily mem­bers, the re­searchers suc­ceeded in iden­ti­fy­ing a key genome mu­ta­tion.

In ad­di­tion, the re­searchers also con­ducted val­i­da­tion stud­ies among more than 1,000 per­sons, some of whom were lung can­cer pa­tients. The re­searchers found that the lung can­cer risk in YAP1 (yes-as­so­ci­ated pro­tein 1) mu­tan­ta­llele car­ri­ers was 5.9 times that of non-car­ri­ers.


Na­tional Tai­wan Univer­sity Pres­i­dent Dr. Pan-chyr Yang, cen­ter, and his team of re­searchers an­nounce their suc­cess­ful iden­ti­fi­ca­tion of a genome mu­ta­tion that could help re­search in lung can­cer, yesterday. The re­search showed pos­i­tive re­sults by us­ing rapid whole-genome se­quenc­ing tech­nol­ogy to dis­cover a gene mu­ta­tion that is linked to lung can­cer; thus, fur­ther aid­ing di­ag­noses of lung can­cer in its early stages.

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