Aspirin may cut bowel can­cer among obese

The China Post - - LIFE GUIDE POST -

Be­ing over­weight more than dou­bles the risk of bowel can­cer in peo­ple with a cer­tain gene dis­or­der, but a reg­u­lar dose of aspirin can re­verse the trend, a study found Mon­day.

The in­ter­na­tional study, pub­lished in the U.S.-based Jour­nal of Clin­i­cal On­col­ogy, fol­lowed 937 peo­ple with an in­her­ited ge­netic dis­or­der known as Lynch Syn­drome in 16 coun­tries, in some cases over a decade.

About half of the peo­ple with the dis­ease even­tu­ally de­velop can­cer. Study par­tic­i­pants took two aspirin tablets (600 mil­ligrams each) or a placebo per day for two years.

The re­searchers at New­cas­tle Univer­sity and the Univer­sity of Leeds in Bri­tain found that be­ing over­weight in­creases the risk of bowel can­cer by 2.75 times.

But par­tic­i­pants who took aspirin had the same risk, whether or not they were obese.

“Obe­sity in­creases the in­flamma- tory re­sponse,” said lead re­searcher John Burn, pro­fes­sor of Clin­i­cal Ge­net­ics at New­cas­tle Univer­sity.

“One ex­pla­na­tion for our find­ings is that the aspirin may be sup­press­ing that in­flam­ma­tion which opens up new av­enues of re­search into the cause of can­cer.”

Burn rec­om­mended, how­ever, that pa­tients con­sult their doc­tor be­fore tak­ing aspirin on a reg­u­lar ba­sis as the drug is known to be as­so­ci­ated with a risk of stom­ach ail­ments such as ul­cers.

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