The Gulf Today - Panorama - - HAVE YOU HEARD? -

Re­searchers have iden­ti­fied a nat­u­rally oc­cur­ring bone hor­mone that can po­ten­tially re­verse mem­ory loss in the age­ing brain through ex­er­cise. The study on the hor­mone os­teo­cal­cin lends new in­sight into how life­style changes that af­fect the body, such as ex­er­cise, could pos­i­tively af­fect the brain.

“Nearly ev­ery­one will ex­pe­ri­ence age-re­lated mem­ory loss in their life­time, so it is in­cred­i­bly im­por­tant to un­der­stand its causes and iden­tify ways to mit­i­gate it,” said Eric R. Kan­del, pro­fes­sor at the Columbia Uni­ver­sity. For many years, mem­ory loss was treated as a sin­gu­lar dis­or­der. But sci­en­tists have now be­gun to re­alise that Alzheimer’s dis­ease be­gins in a part of the brain called the en­torhi­nal cor­tex, which lies at the foot of the hip­pocam­pus.

On the other hand, age-re­lated mem­ory loss be­gins within the hip­pocam­pus it­self. Kan­del’s team iden­ti­fied a de­fi­ciency in a pro­tein called Rbap48 pro­tein, a sig­nif­i­cant con­trib­u­tor to age-re­lated mem­ory loss but not Alzheimer’s. The pro­tein lev­els de­cline with age, both in mice and in peo­ple. Stud­ies in mice showed that mod­er­ate ex­er­cise, such as walk­ing, trig­gers the re­lease of os­teo­cal­cin in the body.

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